Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors 5-(pyridin-2-yl)thiophene-2-carboxamide, 4-(1H-imidazol-1-yl)benzamide, and N-methyl-1-[4-(1H-pyrazol-1-ylmethyl)phenyl]methanamine | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(1H-imidazol-1-yl)benzamide | inhibitor identified by fragment library biophysical screening, induces Trp64 and Trp65 changes to widen the binding site, but also perturbs Tyr25. Binding induces a shift in melting temperature of +4.1 degrees | Mycobacterium tuberculosis | |
5-(pyridin-2-yl)thiophene-2-carboxamide | inhibitor identified by fragment library biophysical screening, induces a strong remodeling of the active site. Compound can inhibit the growth of virulent strains in biotin-deprived media. Binding induces a shift in melting temperature of +6.3 degrees | Mycobacterium tuberculosis | |
N-methyl-1-[4-(1H-pyrazol-1-ylmethyl)phenyl]methanamine | inhibitor identified by fragment library biophysical screening, binding is purely enthalpie-driven. Binding induces a shift in melting temperature of +5.3 degrees | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WQ81 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WQ81 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
bioA | - |
Mycobacterium tuberculosis |