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Literature summary for 2.6.1.5 extracted from

  • Ebara, S.; Nakao, M.; Tomoda, M.; Yamaji, R.; Watanabe, F.; Inui, H.; Nakano, Y.
    Vitamin B12 deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver (2008), Br. J. Nutr., 99, 503-510.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
dexamethasone dexamethasone (5 mg) induces a significant increase in TAT activity, a further increase in TAT activity is not observed in the hepatocytes from the deficient rats, in contrast to the cells from the controls, when glucagon is added simultaneously with dexamethasone Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 2-oxoglutarate
-
 Rattus norvegicus 4-hydroxyphenylpyruvate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
TAT
-
 Rattus norvegicus
tyrosine aminotransferase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus when rats are maintained on a vitamin B12-deficient diet, the activity of tyrosine aminotransferase in the liver is significantly reduced compared with those in the B12-sufficient control rats down