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Literature summary for 2.6.1.5 extracted from
- Hepatic tyrosine aminotransferase from the rainbow lizard Agama agama: purification and some properties (1987), Biochimie, 69, 223-230.
General Stability
| General Stability | Organism |
|---|---|
| 2-oxoglutarate protects against thermal inactivation | Agama agama |
| pyridoxal 5'-phosphate protects against thermal inactivation | Agama agama |
| sensitive to SH inactivation | Agama agama |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag2+ | - |
Agama agama |  |
| Ca2+ | - |
Agama agama | |
| Hg2+ | - |
Agama agama | |
| L-glutamate | competitive inhibition | Agama agama | |
| Mn2+ | - |
Agama agama | |
| Zn2+ | - |
Agama agama | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Agama agama |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Agama agama | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 130000 | - |
- |
Agama agama |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agama agama | - |
rainbow lizard | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, using ammonium sulfate precipitation and several chromatographic steps | Agama agama |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Agama agama | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Agama agama |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 2-oxoglutarate | highly specific for: L-tyrosine | Agama agama | 4-hydroxyphenylpyruvate + L-glutamate | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
2-oxoglutarate protects against thermal inactivation | Agama agama |
| additional information | - |
pyridoxal 5'-phosphate protects against thermal inactivation | Agama agama |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
- |
Agama agama |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition due to L-glutamate | Agama agama |
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