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Literature summary for 2.6.1.5 extracted from

  • Jacoby, G.A.; La Du, B.N.
    Studies on the specificity of tyrosine-alpha-ketoglutarate transaminase (1964), J. Biol. Chem., 239, 419-424.
    View publication on PubMed
Search for more literature for 2.6.1.5

Inhibitors

Inhibitors Comment Organism Structure
(4-hydroxyphenyl)acetic acid 74% inhibition with tyrosine at 3 mM and (4-hydroxyphenyl)acetic acid at 12 mM Rattus norvegicus
3,4-dihydroxyphenylalanine
-
 Rattus norvegicus
3-(3,4-Dihydroxyphenyl)-2-methylalanine
-
 Rattus norvegicus
3-methoxydopamine
-
 Rattus norvegicus
3-Methoxytyrosine
-
 Rattus norvegicus
5-hydroxyindole acetic acid 55% inhibition with tyrosine at 3 mM and 5-hydroxyindole acetic acid at 12 mM Rattus norvegicus
5-hydroxytryptophan 30% inhibition with tyrosine at 3 mM and 5-hydroxytryptophan at 12 mM Rattus norvegicus
alpha-Methyltyrosine
-
 Rattus norvegicus
D-tyrosine 9% inhibition with tyrosine at 3 mM and D-tyrosine at 12 mM Rattus norvegicus
dihydroxymandelic acid 65% inhibition with tyrosine at 3 mM and dihydroxymandelic acid at 3 mM Rattus norvegicus
dihydroxyphenylacetic acid 88% inhibition with tyrosine at 3 mM and dihydroxyphenylacetic acid at 3 mM Rattus norvegicus
dopamine 100% inhibition with tyrosine at 3 mM and dopamine at 12 mM Rattus norvegicus
homovanillic acid
-
 Rattus norvegicus
indole-3-acetic acid 42% inhibition with tyrosine at 3 mM and indole-3-acetic acid at 12 mM Rattus norvegicus
indole-3-butyric acid 71% inhibition with tyrosine at 3 mM and indole-3-butyric acid at 12 mM Rattus norvegicus
Indole-3-propionic acid 48% inhibition with tyrosine at 3 mM and indole-3-propionic acid at 12 mM Rattus norvegicus
norepinephrine competitive inhibition Rattus norvegicus
normetanephrine
-
 Rattus norvegicus
phenylacetic acid 30% inhibition with tyrosine at 3 mM and phenylacetic acid at 12 mM Rattus norvegicus
Phenylethylamine 80% inhibition with tyrosine at 3 mM and phenylethylamine at 12 mM Rattus norvegicus
serotonin 37% inhibition with tyrosine at 3 mM and serotonin at 12 mM Rattus norvegicus
tyramine 13% inhibition with tyrosine at 3 mM and tyramine at 12 mM Rattus norvegicus
vanillylmandelic acid 51% inhibition with tyrosine at 3 mM and vanillylmandelic acid at 3 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
15
-
 L-tyrosine pH 7.9, 37°C Rattus norvegicus
26
-
 3,4-dihydroxyphenylalanine pH 7.9, 37°C Rattus norvegicus
30
-
 tryptophan pH 7.9, 37°C Rattus norvegicus
80
-
 phenylalanine pH 7.9, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 effect of induction with hydrocortisone on activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2-aminophenyl)alanine + 2-oxoglutarate 10% of the activity that with L-tyrosine Rattus norvegicus 3-(4-aminophenyl)-2-oxopropanoate + L-glutamate
-
 ?
(3-fluorophenyl)alanine + 2-oxoglutarate 4% of the activity that with L-tyrosine Rattus norvegicus 3-(3-fluorophenyl)-2-oxopropanoate + L-glutamate
-
 ?
(4-fluorophenyl)alanine + 2-oxoglutarate 7.9% of the activity that with L-tyrosine Rattus norvegicus 3-(4-fluorophenyl)-2-oxopropanoate + L-glutamate
-
 ?
3,4-dihydroxyphenylalanine + 2-oxoglutarate
-
 Rattus norvegicus 3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?
3-aminotyrosine + 2-oxoglutarate 16% of the activity than with L-tyrosine Rattus norvegicus 3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?
3-iodotyrosine + 2-oxoglutarate as effective as L-tyrosine Rattus norvegicus 3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
 ?
L-phenylalanine + 2-oxoglutarate lower activity than with L-tyrosine Rattus norvegicus phenylpyruvate + L-glutamate
-
 ?
L-tyrosine + 2-oxoglutarate maximal activity with L-tyrosine Rattus norvegicus 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
tryptophan + 2-oxoglutarate
-
 Rattus norvegicus 3-indole-2-oxopropanoate + L-glutamate
-
 ?