Literature summary for 2.6.1.45 extracted from

Paszkowski, A.
Some properties of serine: glyoxylate aminotransferase from rye seedlings (Secale cereale L.) (1991), Acta Biochim. Pol., 38, 437-448.

Search for more literature for 2.6.1.45

Inhibitors

Inhibitors	Comment	Organism	Structure
Aminooxyacetate	competitive inhibition	Secale cereale
D-serine	competitive inhibition	Secale cereale
formaldehyde	glyoxylate protects	Secale cereale
glyoxylate	amino acid substrates partially protect	Secale cereale
hydroxylamine	0.1 mM, 70% inhibition	Secale cereale
Isonicotinic acid hydrazide	0.1 mM, 20% inhibition	Secale cereale
SH-group inhibitor	-	Secale cereale

Organism

Organism	UniProt	Comment	Textmining
Secale cereale	-	rye	-

Reaction

Reaction	Comment	Organism	Reaction ID
L-serine + glyoxylate = 3-hydroxypyruvate + glycine	ping pong bi bi mechanism	Secale cereale	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
seedling	7 days old	Secale cereale	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-alanine + glyoxylate	-	Secale cereale	pyruvate + glycine	-	?
L-asparagine + glyoxylate	-	Secale cereale	2-oxosuccinamate + glycine	-	?
L-serine + glyoxylate	-	Secale cereale	3-hydroxypyruvate + glycine	-	r

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	required for activity	Secale cereale
pyridoxal 5'-phosphate	loosely bound	Secale cereale

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00012	-	Aminooxyacetate	-	Secale cereale
1.6	-	D-serine	-	Secale cereale

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Release 2023.1 (January 2023)