Application | Comment | Organism |
---|---|---|
medicine | L-2-aminoadipate, the substrate for AadAT, is a well known astroglial-specific toxin, knowledge of the cerebral disposition of this compound is instrumental for the elucidation of its mechanism of toxicity and possible relevance in pathology | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
kynurenine/alpha-aminoadipate aminotransferase cDNA cloned and expressed in HEK-293 cells | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
2 * 45000, SDS-PAGE | Rattus norvegicus |
47789 | - |
2 * 47789, amino acid residues | Rattus norvegicus |
100000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-aminoadipate + 2-oxoglutarate | Rattus norvegicus | lysine catabolic pathway | 2-oxoadipate + L-glutamate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q64602 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.56 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynurenine + 2-oxoglutarate | - |
Rattus norvegicus | kynurenic acid + L-glutamate | - |
ir | |
L-2-aminoadipate + 2-oxoglutarate | - |
Rattus norvegicus | 2-oxoadipate + L-glutamate | - |
r | |
L-2-aminoadipate + 2-oxoglutarate | lysine catabolic pathway | Rattus norvegicus | 2-oxoadipate + L-glutamate | - |
r | |
additional information | 2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 45000, SDS-PAGE | Rattus norvegicus |
dimer | 2 * 47789, amino acid residues | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
AadAT | - |
Rattus norvegicus |
kynurenine/alpha-aminoadipate aminotransferase | - |
Rattus norvegicus |