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Literature summary for 2.6.1.19 extracted from
- Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase (2012), Bioorg. Med. Chem., 20, 5763-5773.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-(aminomethyl)-1H-pyrrole-2-carboxylic acid | - |
Sus scrofa |  |
| 4-(aminomethyl)furan-2-carboxylic acid | - |
Sus scrofa | |
| 4-(aminomethyl)furan-3-carboxylic acid | - |
Sus scrofa | |
| 4-(aminomethyl)thiophene-2-carboxylic acid | - |
Sus scrofa | |
| 4-(aminomethyl)thiophene-3-carboxylic acid | - |
Sus scrofa | |
| 5-(aminomethyl)-1H-pyrrole-2-carboxylic acid | - |
Sus scrofa | |
| 5-(aminomethyl)furan-2-carboxylic acid | - |
Sus scrofa | |
| 5-(aminomethyl)thiophene-2-carboxylic acid | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.31 | - |
4-(aminomethyl)furan-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 1.3 | - |
4-aminobutanoate | pH 8.5, 25°C | Sus scrofa | |
| 1.4 | - |
4-(aminomethyl)-1H-pyrrole-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 1.7 | - |
4-(aminomethyl)thiophene-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 2.49 | - |
5-(aminomethyl)furan-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 2.8 | - |
4-(aminomethyl)furan-3-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 6.3 | - |
5-(aminomethyl)thiophene-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 9.5 | - |
5-(aminomethyl)-1H-pyrrole-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 10 | - |
4-(aminomethyl)thiophene-3-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(aminomethyl)-1H-pyrrole-2-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 4-(aminomethyl)furan-2-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 4-(aminomethyl)furan-3-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 4-(aminomethyl)thiophene-2-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 4-(aminomethyl)thiophene-3-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 4-aminobutanoate + 2-oxoglutarate | - |
Sus scrofa | 4-oxobutanoate + L-glutamate | - |
? | |
| 5-(aminomethyl)-1H-pyrrole-2-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 5-(aminomethyl)furan-2-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
| 5-(aminomethyl)thiophene-2-carboxylic acid + 2-oxoglutarate | - |
Sus scrofa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GABA-AT | - |
Sus scrofa |
| gamma-aminobutyrate transaminase | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Sus scrofa |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000138 | - |
4-(aminomethyl)furan-3-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.000025 | - |
5-(aminomethyl)-1H-pyrrole-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.0000383 | - |
4-(aminomethyl)furan-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.000056 | - |
4-(aminomethyl)-1H-pyrrole-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.000086 | - |
4-(aminomethyl)thiophene-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.00016 | - |
5-(aminomethyl)thiophene-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.00056 | - |
5-(aminomethyl)furan-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 0.81 | - |
4-aminobutanoate | pH 8.5, 25°C | Sus scrofa | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.35 | - |
4-(aminomethyl)thiophene-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 1.4 | - |
5-(aminomethyl)furan-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 1.59 | - |
4-(aminomethyl)-1H-pyrrole-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 1.64 | - |
4-(aminomethyl)furan-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 2.14 | - |
5-(aminomethyl)-1H-pyrrole-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 2.27 | - |
4-(aminomethyl)furan-3-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 2.49 | - |
5-(aminomethyl)thiophene-2-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
| 2.86 | - |
4-(aminomethyl)thiophene-3-carboxylic acid | pH 8.5, 25°C | Sus scrofa | |
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