Literature summary for 2.6.1.19 extracted from

Yogeeswari, P.; Sriram, D.; Thirumurugan, R.; Jeewanlal, L.R.; Jit, S.; Ragavendran, J.V.; Kavya, R.; Rakhra, K.; Saraswat, V.
Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors (2006), Acta Pharm., 56, 259-272.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2E)-4-methylpentan-2-one N-(2,4-dimethylphenyl)semicarbazone	57% inhibition at 0.125 mM	Pseudomonas fluorescens
(2E)-butan-2-one N-(2,4-dimethylphenyl)semicarbazone	89% inhibition at 0.0625 mM	Pseudomonas fluorescens
2,4-dimethylphenyl semicarbazide hydrochloride	90% inhibition at 0.0625 mM	Pseudomonas fluorescens
propan-2-one N-(2,4-dimethylphenyl)semicarbazone	44% inhibition at 0.25 mM	Pseudomonas fluorescens

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas fluorescens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-aminobutanoate + 2-oxoglutarate	-	Pseudomonas fluorescens	4-oxobutanoate + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
4-aminobutyrate aminotransferase	-	Pseudomonas fluorescens
gamma-aminobutyrate transaminase	-	Pseudomonas fluorescens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Pseudomonas fluorescens

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Release 2023.1 (January 2023)