Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
2-oxoglutarate | 37°C | Sus scrofa | |
1.1 | - |
4-aminobutanoate | 37°C | Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
2 * 55000, liver enzyme, SDS-PAGE | Sus scrofa |
105000 | - |
gel filtration | Sus scrofa |
110000 | - |
liver enzyme, gel filtration | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutanoate + 2-oxoglutarate | Sus scrofa | key-reaction of gamma-aminobutyrate(GABA)-shunt or bypass | 4-oxobutanoate + L-glutamate | - |
? | |
4-aminobutanoate + 2-oxoglutarate | Sus scrofa | involved in beta-alanine metabolism | 4-oxobutanoate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
cationic (I) and anionic (II) form | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.8 | 3.5 | 37°C | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-aminoisobutanoate + 2-oxoglutarate | transamination at 14% the rate of 4-aminobutanoate | Sus scrofa | L-glutamate + 3-oxoisobutanoate | - |
r | |
4-aminobutanoate + 2-oxoglutarate | - |
Sus scrofa | 4-oxobutanoate + L-glutamate | - |
r | |
4-aminobutanoate + 2-oxoglutarate | key-reaction of gamma-aminobutyrate(GABA)-shunt or bypass | Sus scrofa | 4-oxobutanoate + L-glutamate | - |
? | |
4-aminobutanoate + 2-oxoglutarate | involved in beta-alanine metabolism | Sus scrofa | 4-oxobutanoate + L-glutamate | - |
? | |
5-aminopentanoate + 2-oxoglutarate | transamination at 85% the rate of 4-aminobutanoate | Sus scrofa | L-glutamate + 5-oxopentanoate | - |
? | |
beta-alanine + 2-oxoglutarate | effective amino group donor | Sus scrofa | malonic semialdehyde + L-glutamate | - |
r | |
DL-3-hydroxy-4-aminobutanoate + 2-oxoglutarate | transamination at 20% the rate of 4-aminobutanoate | Sus scrofa | L-glutamate + 3-hydroxy-4-oxobutanoate | - |
r | |
additional information | overview | Sus scrofa | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 55000, liver enzyme, SDS-PAGE | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pI: 5.9 and 6.35 (isozyme II), pI: 6.1 and 6.3 (isozyme I) | Sus scrofa |
8.7 | - |
isozyme II | Sus scrofa |
8.8 | - |
isozyme I | Sus scrofa |