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Literature summary for 2.6.1.17 extracted from

  • Cox, R.J.; Sherwin, W.A.; Lam, L.K.P.; Vederas, J.C.
    Synthesis and evaluation of novel substrates and inhibitors of N-succinyl-LL-diaminopimelate aminotransferase (DAP-AT) from Escherichia coli (1996), J. Am. Chem. Soc., 118, 7449-7460.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2-(N-(succinylamino))-6-hydrazinoheptane-1,7-dioic acid very potent slow-binding inhibitor, synthesis Escherichia coli
2-(N-Carbobenzoxy-amino)-6-hydrazinoheptane-1,7-dioic acid very potent slow-binding inhibitor, synthesis Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
N-Succinyl-2-amino-6-oxoheptanedioate 30°C, pH 8.0 Escherichia coli
1.21
-
L-glutamate 30°C, pH 8.0 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39900
-
2 * 39900, SDS-PAGE, MALDI-TOF mass spectra Escherichia coli
82000
-
gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Escherichia coli a key enzyme in the bacterial pathway to L-lysine N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information structural requirements for substrate recognition Escherichia coli ?
-
?
N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate i.e. N-succinyl-alpha-amino-epsilon-ketopimelic acid Escherichia coli N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
r
N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate a key enzyme in the bacterial pathway to L-lysine Escherichia coli N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 39900, SDS-PAGE, MALDI-TOF mass spectra Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000004
-
2-(N-(succinylamino))-6-hydrazinoheptane-1,7-dioic acid 30°C, pH 8.0 Escherichia coli
0.000054
-
2-(N-Carbobenzoxy-amino)-6-hydrazinoheptane-1,7-dioic acid 30°C, pH 8.0 Escherichia coli