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Literature summary for 2.6.1.16 extracted from

  • Floquet, N.; Richez, C.; Durand, P.; Maigret, B.; Badet, B.; Badet-Denisot, M.A.
    Discovering new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations (2007), Bioorg. Med. Chem. Lett., 17, 1966-1970.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-amino-2-deoxy-D-glucitol-6-phosphate IC50: 0.056 mM Escherichia coli
4-(furan-2-ylcarbonyl)-3-hydroxy-5-(4-phenoxyphenyl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one 20% inhibition at 0.1 mM Escherichia coli
6,7-bis(2-methoxyphenyl)-10-methyl-1,4,7,12-tetrahydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine 70% inhibition at 0.1 mM Escherichia coli
Aaptamine IC50: 0.12 mM Escherichia coli
amitrole IC50: 0.1 mM Escherichia coli
ethyl 2-[2-(3-bromophenyl)-3-[(4-fluorophenyl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol 1-yl]-4-methyl-1,3-thiazole-5-carboxylate 70% inhibition at 0.1 mM Escherichia coli
ethyl 2-[3-[(4-fluorophenyl)carbonyl]-4-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydro-1H pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate 70% inhibition at 0.1 mM Escherichia coli
additional information no inhibition by 0.1 mM c3, 4, 6, 9, 12, 13 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P17169
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + D-fructose 6-phosphate
-
Escherichia coli L-glutamate + D-glucosamine 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
GlmS
-
Escherichia coli
glucosamine-6-P synthase
-
Escherichia coli
L-glutamine:L-fructose-6-phosphate amidotransferase
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.056
-
IC50: 0.056 mM Escherichia coli 2-amino-2-deoxy-D-glucitol-6-phosphate
0.1
-
IC50: 0.1 mM Escherichia coli amitrole
0.12
-
IC50: 0.12 mM Escherichia coli Aaptamine