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Literature summary for 2.6.1.100 extracted from
- First identification of Streptomyces genes involved in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics: genetic and evolutionary analysis of L-glutamine:2-deoxy-scyllo-inose aminotransferase genes (2002), J. Antibiot., 55, 1016-1018.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 | Streptomyces fradiae |
| gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 | Streptoalloteichus hindustanus |
| gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 | Streptomyces ribosidificus |
| gene btrS, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, expression in Escherichia coli strain JM109 | Streptomyces kanamyceticus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces fradiae | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? |  |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptoalloteichus hindustanus | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces ribosidificus | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces kanamyceticus | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces ribosidificus JCM 4923 | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces kanamyceticus JCM 4433 | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces fradiae IFO13147 | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | Streptomyces fradiae IFO12773 | - |
2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Streptomyces lividans | - |
strain TK24 | - |
| Streptoalloteichus hindustanus | Q6F6I1 | gene btrS or alloG | - |
| Streptomyces fradiae | Q53U20 | gene btrS, neoB, nemB, neo6, neoS, or nmcS | - |
| Streptomyces fradiae IFO12773 | Q53U20 | gene btrS, neoB, nemB, neo6, neoS, or nmcS | - |
| Streptomyces fradiae IFO13147 | Q53U20 | gene btrS, neoB, nemB, neo6, neoS, or nmcS | - |
| Streptomyces kanamyceticus | Q6L739 | gene btrS | - |
| Streptomyces kanamyceticus JCM 4433 | Q6L739 | gene btrS | - |
| Streptomyces ribosidificus | Q4R0W2 | gene btrS, rbmB, rbcS, or ribS; gene btrS | - |
| Streptomyces ribosidificus JCM 4923 | Q4R0W2 | gene btrS, rbmB, rbcS, or ribS; gene btrS | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces fradiae | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptoalloteichus hindustanus | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces ribosidificus | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces kanamyceticus | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces ribosidificus JCM 4923 | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces kanamyceticus JCM 4433 | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces fradiae IFO13147 | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
| L-glutamine + 2-deoxy-scyllo-inosose | - |
Streptomyces fradiae IFO12773 | 2-oxoglutaramate + 2-deoxy-scyllo-inosamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BtrS | - |
Streptomyces fradiae |
| BtrS | - |
Streptoalloteichus hindustanus |
| BtrS | - |
Streptomyces ribosidificus |
| BtrS | - |
Streptomyces kanamyceticus |
| L-glutamine:DOI aminotransferase | - |
Streptomyces fradiae |
| L-glutamine:DOI aminotransferase | - |
Streptoalloteichus hindustanus |
| L-glutamine:DOI aminotransferase | - |
Streptomyces ribosidificus |
| L-glutamine:DOI aminotransferase | - |
Streptomyces kanamyceticus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved in the biosynthesis of kanamycin | Streptomyces kanamyceticus |
| metabolism | the enzyme is involved in the biosynthesis of neomycin | Streptomyces fradiae |
| metabolism | the enzyme is involved in the biosynthesis of ribostamycin | Streptomyces ribosidificus |
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