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Literature summary for 2.6.1.1 extracted from
- Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formation (2006), Neurochem. Int., 48, 629-636.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| malate | 5 mM | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-glutamate | 5 mM, significant inhibition | Rattus norvegicus | |
| MgCl2 | 2 mM | Rattus norvegicus | |
| palmitate | 0.1 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.47 | - |
2-oxoglutarate | enzyme from nonsynaptic mitochondrion, pH 7.8, 30°C | Rattus norvegicus | |
| 1.95 | - |
2-oxoglutarate | enzyme from synaptic mitochondrion, pH 7.8, 30°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-aspartate + 2-oxoglutarate | - |
Rattus norvegicus | oxaloacetate + L-glutamate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AAT | - |
Rattus norvegicus |
| aspartate aminotransferase | - |
Rattus norvegicus |
| L-aspartate:2-oxoglutarate aminotransferase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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