Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | substrate inhibition at high concentration | Trichomonas vaginalis | |
adipate | no inhibition | Trichomonas vaginalis | |
L-glutamate | competitive | Trichomonas vaginalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.062 | - |
2-oxoglutarate | 30°C | Trichomonas vaginalis | |
0.96 | - |
L-aspartate | 30°C | Trichomonas vaginalis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
44000 | - |
2 * 44000, mitochondria, SDS-PAGE | Trichomonas vaginalis |
100000 | - |
gel filtration | Trichomonas vaginalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | Trichomonas vaginalis | - |
oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | Trichomonas vaginalis Bushby | - |
oxaloacetate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trichomonas vaginalis | - |
Bushby strain | - |
Trichomonas vaginalis Bushby | - |
Bushby strain | - |
Purification (Comment) | Organism |
---|---|
200-1000fold, copurification with the aromatic amino acid aminotransferase 2.6.1.57 | Trichomonas vaginalis |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate | bi bi ping pong reaction kinetic | Trichomonas vaginalis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
172 | - |
purified enzyme | Trichomonas vaginalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 2-oxoglutarate | - |
Trichomonas vaginalis | pyruvate + L-glutamate | - |
? | |
L-alanine + 2-oxoglutarate | - |
Trichomonas vaginalis Bushby | pyruvate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Trichomonas vaginalis | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Trichomonas vaginalis | oxaloacetate + L-glutamate | - |
r | |
L-aspartate + 2-oxoglutarate | - |
Trichomonas vaginalis Bushby | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Trichomonas vaginalis Bushby | oxaloacetate + L-glutamate | - |
r | |
L-phenylalanine + 2-oxoglutarate | - |
Trichomonas vaginalis | 2-oxo-3-phenylpropionic acid + L-glutamate | i.e. phenylpyruvate | ? | |
L-tryptophan + 2-oxoglutarate | - |
Trichomonas vaginalis | 3-indole-2-oxopropionic acid + L-glutamate | - |
? | |
L-tyrosine + 2-oxoglutarate | - |
Trichomonas vaginalis | 3-(4-hydroxyphenyl)-2-oxopropionic acid + L-glutamate | i.e. 4-hydroxyphenylpyruvate | ? | |
additional information | substrate specificity | Trichomonas vaginalis | ? | - |
? | |
additional information | no activity with L-cysteine, L-isoleucine, L-leucine, L-valine, L-glutamine, glycine, L-ornithine, L-lysine, L-arginine | Trichomonas vaginalis | ? | - |
? | |
additional information | substrate specificity | Trichomonas vaginalis Bushby | ? | - |
? | |
additional information | no activity with L-cysteine, L-isoleucine, L-leucine, L-valine, L-glutamine, glycine, L-ornithine, L-lysine, L-arginine | Trichomonas vaginalis Bushby | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 44000, mitochondria, SDS-PAGE | Trichomonas vaginalis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.8 | - |
L-glutamate | 30°C, competitive versus L-aspartate | Trichomonas vaginalis | |
6.8 | - |
L-glutamate | 30°C, competitive versus 2-oxoglutrate | Trichomonas vaginalis | |
30 | - |
2-oxoglutarate | 30°C, substrate inhibition | Trichomonas vaginalis |