Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
modeling for the binding of two molecules of inhibitor 5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil in the active site | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil | comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase | Escherichia coli | |
5-(4-phosphonopentyryl)amino-6-D-ribitylaminouracil | comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase | Escherichia coli | |
5-(5-phosphonoxyvaleryl)amino-6-D-ribitylaminouracil | mixed inhibition, comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase | Escherichia coli | |
5-(hexyl 6-dihydrogen phosphate)-6-([(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino)pyrimidine-2,4(1H,3H)-dione | mixed inhibition, comparison with inhibition of Bacillus subtilis luminazine synthase/riboflavin synthase | Escherichia coli | |
additional information | incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase versus lumazine synthase | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0068 | - |
5-(4-phosphonopentyryl)amino-6-D-ribitylaminouracil | pH 7.5, 37°C | Escherichia coli | |
0.16 | - |
5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil | pH 7.5, 37°C | Escherichia coli | |
0.19 | - |
5-(5-phosphonoxyvaleryl)amino-6-D-ribitylaminouracil | pH 7.5, 37°C | Escherichia coli | |
1 | - |
5-(hexyl 6-dihydrogen phosphate)-6-([(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino)pyrimidine-2,4(1H,3H)-dione | pH 7.5, 37°C | Escherichia coli |