Application | Comment | Organism |
---|---|---|
biotechnology | fluorochemical production (18F-labelled organic compounds) for medicinal chemistry research (positron emission tomography), when enzyme acts together with other enzymes in the fluorometabolite production (purine nucleoside phosphorylase, isomerase, aldolase, enzyme generating fluoroacetaldehyde in a retro-aldol reaction, fluoroacetaldehyde dehydrogenase or pyridoxal phosphate-dependent enzyme) to generate fluoroacetaldehyde and 4-fluorothreonine | Streptomyces cattleya |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21 | Streptomyces cattleya |
expression in Escherichia coli BL21(DE3) | Streptomyces cattleya |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + fluoride | Streptomyces cattleya | - |
5'-deoxy-5'-fluoroadenosine + L-methionine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces cattleya | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptomyces cattleya |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + fluoride | - |
Streptomyces cattleya | 5'-deoxy-5'-fluoroadenosine + L-methionine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5'-fluoro-5'-deoxyadenosine synthase | - |
Streptomyces cattleya |
flA | - |
Streptomyces cattleya |
flA protein | - |
Streptomyces cattleya |
fluorinase | - |
Streptomyces cattleya |
General Information | Comment | Organism |
---|---|---|
metabolism | first enzyme in the fluorometabolite pathway to produce the mammalian toxin fluoroacetate and the antibiotic 4-fluorothreonine | Streptomyces cattleya |
physiological function | part of 4-fluorothreonine biosynthesis | Streptomyces cattleya |