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Literature summary for 2.5.1.60 extracted from

  • Goody, R.S.; Rak, A.; Alexandrov, K.
    The structural and mechanistic basis for recycling of Rab proteins between membrane compartments (2005), Cell. Mol. Life Sci., 62, 1657-1670.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + Rab protein Saccharomyces cerevisiae Rab proteins are members of the Ras superfamily of GTPases and are key regulators of intracellular vesicular transport, they undergo a cycle of GTPase activity, and this activity is interconnected to a cycle of reversible attachment to membranes. This cycle is mediated by geranylgeranylation of usually two C-terminal cysteines, which in turn is effected by Rab geranylgeranyltransferase in concert with Rab escort protein REP, Rab prenylation, delivery to membranes and the GTPase cycle, overview, alternative and classical pathways, overview S-geranylgeranyl-Rab protein + diphosphate
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additional information Saccharomyces cerevisiae structural and mechanistic basis for recycling of Rab proteins between membrane compartments, overview ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Reaction

Reaction Comment Organism Reaction ID
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate prenylation mechanism of Rab potein by the RabGGTase:GGpp complex, overview Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + Rab protein
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Saccharomyces cerevisiae S-geranylgeranyl-Rab protein + diphosphate
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?
geranylgeranyl diphosphate + Rab protein Rab proteins are members of the Ras superfamily of GTPases and are key regulators of intracellular vesicular transport, they undergo a cycle of GTPase activity, and this activity is interconnected to a cycle of reversible attachment to membranes. This cycle is mediated by geranylgeranylation of usually two C-terminal cysteines, which in turn is effected by Rab geranylgeranyltransferase in concert with Rab escort protein REP, Rab prenylation, delivery to membranes and the GTPase cycle, overview, alternative and classical pathways, overview Saccharomyces cerevisiae S-geranylgeranyl-Rab protein + diphosphate
-
?
additional information structural and mechanistic basis for recycling of Rab proteins between membrane compartments, overview Saccharomyces cerevisiae ?
-
?
additional information the enzyme is complexed with the Rab escort protein, REP, which is essential for enzyme activity, binary complex structure, overview Saccharomyces cerevisiae ?
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?

Synonyms

Synonyms Comment Organism
Rab geranylgeranyl transferase
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Saccharomyces cerevisiae
RabGGTase
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Saccharomyces cerevisiae