Application | Comment | Organism |
---|---|---|
medicine | RabGGT is a therapeutically relevant target for modulation of apoptosis | Homo sapiens |
medicine | RabGGT is a therapeutically relevant target for modulation of apoptosis | Caenorhabditis elegans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BMS1 | - |
Caenorhabditis elegans | |
BMS2 | - |
Caenorhabditis elegans | |
BMS3 | - |
Caenorhabditis elegans | |
BMS4 | - |
Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis | ? | - |
? | |
additional information | Caenorhabditis elegans | reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
colonic cancer cell | adenocarcinoma of colon, significant overexpression of RabGGT-beta compared to normal tissue | Homo sapiens | - |
kidney tumor cell | - |
Homo sapiens | - |
lung cancer cell | large cell lung carcinomas, significant overexpression of RabGGT-beta compared to normal tissue | Homo sapiens | - |
melanoma cell | significant overexpression of RabGGT-beta and Rab-GGT-alpha compared to normal tissue | Homo sapiens | - |
ovary cancer cell | significant overexpression of RabGGT-beta and RabGGT-alpha compared to normal tissue | Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
uterine cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis | Homo sapiens | ? | - |
? | |
additional information | reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis | Caenorhabditis elegans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rab geranylgeranyl transferase | - |
Homo sapiens |
Rab geranylgeranyl transferase | - |
Caenorhabditis elegans |
RabGGT | - |
Homo sapiens |
RabGGT | - |
Caenorhabditis elegans |