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Literature summary for 2.5.1.60 extracted from

  • Lackner, M.R.; Kindt, R.M.; Carroll, P.M.; Brown, K.; Cancilla, M.R.; Chen, C.; de Silva, H.; Franke, Y.; Guan, B.; Heuer, T.; Hung, T.; Keegan, K.; Lee, J.M.; Manne, V.; O'Brien, C.; Parry, D.; Perez-Villar, J.J.; Reddy, R.K.; Xiao, H.; Zhan, H.; Cockett, M.; Plowman, G.; Fitzgerald, K.; Costa, M.; Ross-Macdonald, P.
    Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors (2005), Cancer Cell, 7, 325-336.
    View publication on PubMed

Application

Application Comment Organism
medicine RabGGT is a therapeutically relevant target for modulation of apoptosis Homo sapiens
medicine RabGGT is a therapeutically relevant target for modulation of apoptosis Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
BMS1
-
Caenorhabditis elegans
BMS2
-
Caenorhabditis elegans
BMS3
-
Caenorhabditis elegans
BMS4
-
Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis ?
-
?
additional information Caenorhabditis elegans reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis ?
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
colonic cancer cell adenocarcinoma of colon, significant overexpression of RabGGT-beta compared to normal tissue Homo sapiens
-
kidney tumor cell
-
Homo sapiens
-
lung cancer cell large cell lung carcinomas, significant overexpression of RabGGT-beta compared to normal tissue Homo sapiens
-
melanoma cell significant overexpression of RabGGT-beta and Rab-GGT-alpha compared to normal tissue Homo sapiens
-
ovary cancer cell significant overexpression of RabGGT-beta and RabGGT-alpha compared to normal tissue Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
uterine cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis Homo sapiens ?
-
?
additional information reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis Caenorhabditis elegans ?
-
?

Synonyms

Synonyms Comment Organism
Rab geranylgeranyl transferase
-
Homo sapiens
Rab geranylgeranyl transferase
-
Caenorhabditis elegans
RabGGT
-
Homo sapiens
RabGGT
-
Caenorhabditis elegans