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Literature summary for 2.5.1.6 extracted from

  • Taylor, J.C.; Bock, C.W.; Takusagawa, F.; Markham, G.D.
    Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening (2009), J. Med. Chem., 52, 5967-5973.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
1-(3-(2-ethoxyphenyl)ureidoacetyl)-4-(2-methyl-5-nitrophenyl)semicarbazide binding to adenosyl region of the active site Escherichia coli
1-(4-chloro-2-nitrophenyl)-3-(4-sulfamoylphenyl)-urea binding to adenosyl region of the active site Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A817
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000019
-
 pH 8.0, 25°C Escherichia coli 1-(3-(2-ethoxyphenyl)ureidoacetyl)-4-(2-methyl-5-nitrophenyl)semicarbazide
0.0000069
-
 pH 8.0, 25°C Escherichia coli 1-(4-chloro-2-nitrophenyl)-3-(4-sulfamoylphenyl)-urea