Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Dimethylsulfoxide | activates isoform from kidney and isoform MAT-III from liver | Rattus norvegicus | |
S-adenosylmethionine | activation of rat liver MAT-III | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dimethylsulfoxide | weak inhibition of liver isoenzyme | Rattus norvegicus | |
S-adenosylmethionine | inhibition of rat kidney enzyme and rat liver MAT-II, weak inhibition of rat liver MAT-I | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0083 | - |
methionine | MAT-II isoenzyme | Rattus norvegicus | |
0.041 | - |
L-methionine | MAT-I isoenzyme | Rattus norvegicus | |
0.215 | - |
L-methionine | MAT-III isoenzyme | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47000 | - |
2 * 47000, MAT-III, SDS-PAGE | Rattus norvegicus |
97000 | - |
MAT-III, gel filtration | Rattus norvegicus |
120000 | - |
MAT-II, isolated from kidney and liver, gel filtration | Rattus norvegicus |
208000 | - |
MAT-I, gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
3 isoenzymes: MAT-I, MAT-II, MAT-III | - |
Purification (Comment) | Organism |
---|---|
three isoforms: MAT-I, MAT-II and MAT-III, MAT-III to homogeneity | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxy-ATP + L-methionine + H2O | - |
Rattus norvegicus | ? | - |
? | |
3'-deoxy-ATP + L-methionine + H2O | - |
Rattus norvegicus | ? | - |
? | |
ATP + L-methionine + H2O | - |
Rattus norvegicus | S-adenosyl-L-methionine + phosphate + diphosphate | - |
? | |
ATP + methionine + H2O | - |
Rattus norvegicus | S-adenosyl-L-methionine + phosphate + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 47000, MAT-III, SDS-PAGE | Rattus norvegicus |