Literature summary for 2.5.1.59 extracted from

Ghavami, S.; Mutawe, M.; Schaafsma, D.; Yeganeh, B.; Unruh, H.; Klonisch, T.; Halayko, A.
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle (2012), Am. J. Physiol. Lung Cell Mol. Physiol., 302, L420-L428.

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Inhibitors

Inhibitors	Comment	Organism	Structure
GGTI-298	treatment of airway smooth muscle cells induces expression of p53-dependent proteins, p53 upregulated modulator of apoptosis Noxa, and damage-regulated autophagy modulator DRAM, this is inhibited by the p53 transcriptional activation inhibitor cyclic-pifithrin-alpha. Inhibition of autophagy with bafilomycin-A1 or short-hairpin RNA silencing of Atg7 substantially augments GGTI-298-induced apoptosis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
smooth muscle cell	primary culture of airway smooth muscle cell	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	pharmacological inhibition of protein geranylgeranyltransferase-I induces simultaneous p53-dependent apoptosis and autophagy in airway smooth muscle cells, and autophagy regulates apoptosis induction	Homo sapiens

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Release 2023.1 (January 2023)