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Literature summary for 2.5.1.59 extracted from

  • Arellano, M.; Coll, P.M.; Yang, W.; Duran, A.; Tamanol, F.; Perez, P.
    Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe (1998), Mol. Microbiol., 29, 1357-1367.
    View publication on PubMed
Search for more literature for 2.5.1.59

Cloned(Commentary)

Cloned (Comment) Organism
identification of the cwp1+ gene, which encodes the alpha-subunit of enzyme, coexpression of cwp1p and cwg2p, beta-subunit, in Escherichia coli Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
additional information Cwg2-1 mutant has a defect in the actin organization, this mutant is identified as a single nucleotide change causing an A202T substitution in a residue conserved among the beta-subunit of enzyme, the deletion of cwg2 causes cell death Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine Schizosaccharomyces pombe this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites S-geranylgeranyl-protein + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
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Reaction

Reaction Comment Organism Reaction ID
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate this enzyme, along with protein farnesyltransferase, EC 2.5.1.58 and protein geranylgeranyltransferase type II, EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes Schizosaccharomyces pombe
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X Schizosaccharomyces pombe S-geranylgeranyl-protein + diphosphate
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 ?
geranylgeranyl diphosphate + protein-cysteine this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites Schizosaccharomyces pombe S-geranylgeranyl-protein + diphosphate
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 ?
additional information requires geranylgeranylation of rho1p for the correct function of enzyme Schizosaccharomyces pombe ?
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 ?