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Literature summary for 2.5.1.55 extracted from

  • Tao, P.; Schlegel, H.B.; Gatti, D.L.
    Common basis for the mechanism of metallo and non-metallo KDO8P synthases (2010), J. Inorg. Biochem., 104, 1267-1275.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
synthetic construct
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Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate quantum mechanical/molecular mechanical simulations of both the enzymatic and non-enzymatic synthesis of 2-dehydro-3-deoxy-D-octonate 8-phosphate reveal the mechanism underlying the switch between metal and non-metal dependent catalysis. The conversion is possible because the metal is not involved in an activation process, but primarily contributes to orienting properly the reactants to lower the activation energy, an action easily mimicked by amino acid side-chains synthetic construct