Organism | UniProt | Comment | Textmining |
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synthetic construct | - |
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Reaction | Comment | Organism | Reaction ID |
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phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate | quantum mechanical/molecular mechanical simulations of both the enzymatic and non-enzymatic synthesis of 2-dehydro-3-deoxy-D-octonate 8-phosphate reveal the mechanism underlying the switch between metal and non-metal dependent catalysis. The conversion is possible because the metal is not involved in an activation process, but primarily contributes to orienting properly the reactants to lower the activation energy, an action easily mimicked by amino acid side-chains | synthetic construct |