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Literature summary for 2.5.1.55 extracted from

  • Baasov, T.; Sheffer-Dee-Noor, S.; Kohen, A.; Jakob, A.; Belakhov, V.
    Catalytic mechanism of 3-deoxy-D-manno-octulosonate-8-phosphate synthase. The use of synthetic analogues to probe the structure of the putative reaction intermediate (1993), Eur. J. Biochem., 217, 991-999.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,6-Anhydro-3-deoxy-2beta-phosphonylmethyl-8-phosphate-D-glycero-D-talo-octonate most potent inhibitor Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate mechanism Escherichia coli
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate bisphosphate intermediate formed during the initial step of synthesis may have the pyranose structure with the anomeric phosphate located in the beta-configuration Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-arabinose 5-phosphate
-
Escherichia coli 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.6
-
2,6-Anhydro-3-deoxy-2beta-phosphonylmethyl-8-phosphate-D-glycero-D-talo-octonate pH 7.3, 37°C Escherichia coli