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Literature summary for 2.5.1.54 extracted from

  • Hu, C.; Jiang, P.; Xu, J.; Wu, Y.; Huang, W.
    Mutation analysis of the feedback inhibition site of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Escherichia coli (2003), J. Basic Microbiol., 43, 399-406.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
F144A inhibition by phenylalanine, 30% residual activity Escherichia coli
F209A inhibition by phenylalanine, 79% residual activity Escherichia coli
I10A inhibition by phenylalanine, 95% residual activity Escherichia coli
L175A inhibition by phenylalanine, 18% residual activity Escherichia coli
L175D inhibition by phenylalanine, 83% residual activity Escherichia coli
L175Q inhibition by phenylalanine, 44% residual activity Escherichia coli
L179A inhibition by phenylalanine, 82% residual activity Escherichia coli
additional information N-terminal deletion mutant, no inhibition by phenylalanine Escherichia coli
N5K inhibition by phenylalanine, 33% residual activity Escherichia coli
P150L inhibition by phenylalanine, no inhibition by phenylalanine Escherichia coli
V221A inhibition by phenylalanine, 95% residual activity Escherichia coli
W215A inhibition by phenylalanine, 58% residual activity Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
phenylalanine 1 Mn, wild-type 8.2% residual activity Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
isoform AroG
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.29
-
N-terminal deletion mutant, 37°C, pH 6.4 Escherichia coli
0.81
-
mutant W215A, 37°C, pH 6.4 Escherichia coli
0.92
-
mutant I10A, 37°C, pH 6.4 Escherichia coli
1.97
-
mutant N5K, 37°C, pH 6.4 Escherichia coli
2.37
-
mutant V221A, 37°C, pH 6.4 Escherichia coli
2.7
-
wild-type, 37°C, pH 6.4 Escherichia coli
2.81
-
mutant L179A, 37°C, pH 6.4 Escherichia coli
2.81
-
mutant P150L, 37°C, pH 6.4 Escherichia coli
3.07
-
mutant F144A, 37°C, pH 6.4 Escherichia coli
3.25
-
mutant F209A, 37°C, pH 6.4 Escherichia coli
3.6
-
mutant L175Q, 37°C, pH 6.4 Escherichia coli
4.25
-
mutant L175A, 37°C, pH 6.4 Escherichia coli
4.46
-
mutant L175D, 37°C, pH 6.4 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Escherichia coli 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate
-
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