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Literature summary for 2.5.1.54 extracted from

  • Wu, J.; Sheflyan, G.Y.; Woodard, R.W.
    Bacillus subtilis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase revisited: resolution of two long-standing enigmas (2005), Biochem. J., 390, 583-590.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
chorismate 1 mM, 3% residual activity Bacillus subtilis
dipicolinic acid inactivation, reactivation by divalent cations Bacillus subtilis
L-phenylalanine 1 mM, 3% residual activity Bacillus subtilis
L-tryptophan 1 mM, 3% residual activity Bacillus subtilis
L-tyrosine 1 mM, 3% residual activity Bacillus subtilis
additional information no inhibitory: EDTA Bacillus subtilis
prephenate 1 mM, 3% residual activity Bacillus subtilis
shikimate 1 mM, 3% residual activity Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.139
-
phosphoenolpyruvate pH 7.5, 37°C Bacillus subtilis
1.76
-
D-erythrose 4-phosphate pH 7.5, 37°C Bacillus subtilis

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
Bacillus subtilis
Zn2+
-
Bacillus subtilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
156000
-
gel filtration Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
Marburg strain and strain 168, bifunctional enzyme with chorismate mutase activity in addition to enzymic activity
-

Renatured (Commentary)

Renatured (Comment) Organism
reactivation of dipicolinic acid-inactivated enzyme by divalent cations Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Bacillus subtilis 3-deoxy-D-erythro-hept-2-ulosonate 7-phosphate + phosphate
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 4000, SDS-PAGE Bacillus subtilis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.6
-
phosphoenolpyruvate pH 7.5, 37°C Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Bacillus subtilis

pH Range

pH Minimum pH Maximum Comment Organism
8.5 9.5 more than 85% of maximum activity Bacillus subtilis