Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Phe | DSI; Phe-sensitive isozyme | Amycolatopsis methanolica | |
Trp | DSI; Trp-sensitive isozyme | Amycolatopsis methanolica | |
Tyr | DSI and DSII; Tyr-sensitive isozyme | Amycolatopsis methanolica |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.4 | - |
phosphoenolpyruvate | isozyme DS II, pH 7.5, 37°C | Amycolatopsis methanolica | |
1.1 | - |
D-erythrose 4-phosphate | DS II isozyme, pH 7.5, 37°C | Amycolatopsis methanolica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | Amycolatopsis methanolica | key regulatory enzyme in L-Phe and L-Tyr biosynthesis | 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Amycolatopsis methanolica | - |
wild type strain WV2 contains DS I, a leaky L-Phe-requiring auxotroph mutant strain GH141 grown under L-Phe limitation possesses additional DS II activity | - |
Purification (Comment) | Organism |
---|---|
- |
Amycolatopsis methanolica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | - |
Amycolatopsis methanolica | 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate | - |
? | |
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | key regulatory enzyme in L-Phe and L-Tyr biosynthesis | Amycolatopsis methanolica | 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate | - |
? |