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Literature summary for 2.5.1.54 extracted from

  • Ip, K.M.; Doy, C.H.
    The kinetic of a purified form of 3-deoxy-D-arabino heptulosonate-7-phosphate synthase (tryptophan) from Neurospora crassa (1979), Eur. J. Biochem., 98, 431-440.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
D-erythrose 4-phosphate substrate-inhibition Neurospora crassa
phosphate competitive to D-erythrose 4-phosphate, noncompetitive to phosphoenolpyruvate Neurospora crassa
Trp allosteric, best at pH 6.0, no inhibition at pH 7.3; Trp-sensitive isozyme Neurospora crassa

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-
Neurospora crassa
-
tryptophan-sensitive isozyme
-
Neurospora crassa 74A
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Neurospora crassa

Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate ordered ping-pong bi-bi mechanism Neurospora crassa
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate first substrate is phosphoenolpyruvate Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Neurospora crassa 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
?
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Neurospora crassa 74A 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
phosphoenolpyruvate, D-erythrose 4-phosphate and inorganic phosphate protect the purified enzyme against heat denaturation Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
tryptophan-sensitive isozyme Neurospora crassa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
22
-
phosphate slope, tryptophan-sensitive isozyme, versus phosphoenolpyruvate, pH 7.4, 37°C Neurospora crassa
25
-
phosphate slope, tryptophan-sensitive isozyme, versus D-erythrose 4-phosphate, pH 7.4, 37°C Neurospora crassa
54
-
phosphate intercept, tryptophan-sensitive isozyme, versus phosphoenolpyruvate, pH 7.4, 37°C Neurospora crassa