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Literature summary for 2.5.1.54 extracted from

  • McCandliss, R.J.; Poling, M.D.; Herrmann, K.M.
    3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification and molecular characterization of the phenylalanine-sensitive isoenzyme from Escherichia coli (1978), J. Biol. Chem., 253, 4259-4265.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
beta-2-Thienyl-D,L-Ala
-
Escherichia coli
dihydroxyphenylalanine
-
Escherichia coli
Phe L-Phe; Phe-sensitive isozyme; strong Escherichia coli
Tyr Tyr-sensitive isozyme Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ no effect Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
4 * 35000, Phe-sensitive isozyme, SDS-PAGE Escherichia coli
136000
-
equilibrium sedimentation Escherichia coli
140000
-
gel filtration and sedimentation equilibrium analysis Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli
-
K12
-
Escherichia coli
-
phenylalanine-sensitive isozyme
-
Escherichia coli HE 401
-
-
-

Purification (Commentary)

Purification (Comment) Organism
683fold Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
82.6
-
purified enzyme Escherichia coli

Storage Stability

Storage Stability Organism
-20°C, in phosphate buffer containing phosphoenolpyruvate, stable for several months Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Escherichia coli 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
?
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Escherichia coli HE 401 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 35000, Phe-sensitive isozyme, SDS-PAGE Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
6 8.5 pH 6.0: about 65% of maximal activity, pH 8.5: about 50% of maximal activity Escherichia coli