Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.54 extracted from

  • DeLeo, A.B.; Dayan, J.; Sprinson, D.B.
    Purification and kinetics of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthetase from Salmonella (1973), J. Biol. Chem., 248, 2344-2353.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Co2+ concentrations above 0.1 mM Salmonella enterica subsp. enterica serovar Typhimurium
EDTA no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
phosphate phosphate buffer destabilizes Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Salmonella enterica subsp. enterica serovar Typhimurium
0.013
-
D-erythrose 4-phosphate pH 7.4, 37°C Salmonella enterica subsp. enterica serovar Typhimurium
0.015
-
phosphoenolpyruvate pH 7.4, 37°C Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ not required, Co2+ is inhibitory at concentrations above 0.1 mM Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
gel filtration Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O Salmonella enterica subsp. enterica serovar Typhimurium first enzyme of the aromatic amino acid biosynthesis 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
tyrosine-sensitive isozyme
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
operator-constitutive strain tyrO
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

Reaction Comment Organism Reaction ID
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate sequential mechanism Salmonella enterica subsp. enterica serovar Typhimurium
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate ordered ping-pong bi-bi mechanism Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
18.5
-
purified enzyme Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
r
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O first enzyme of the aromatic amino acid biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
Hepes buffer Salmonella enterica subsp. enterica serovar Typhimurium

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information product inhibition pattern Salmonella enterica subsp. enterica serovar Typhimurium