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Literature summary for 2.5.1.48 extracted from

  • Kong, Y.; Wu, D.; Bai, H.; Han, C.; Chen, J.; Chen, L.; Hu, L.; Jiang, H.; Shen, X.
    Enzymatic characterization and inhibitor discovery of a new cystathionine gamma-synthase from Helicobacter pylori (2008), J. Biochem., 143, 59-68.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Helicobacter pylori

Inhibitors

Inhibitors Comment Organism Structure
(1S,3aS,4R,6aR)-1,4-bis(1,3-benzodioxol-5-yl)hexahydropentalen-3a(1H)-ol i.e. paulownin, NPLC604, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 15 mg/ml Helicobacter pylori
(1S,3aS,4S,6aS)-1,4-di(3,4,5-trimethoxy)-phenyloctahydropentalene i.e. yangambin, NPLC605, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 10 mg/ml Helicobacter pylori
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione i.e. alpha-lapachone, NPLC518, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 2.6 mg/ml Helicobacter pylori
6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione i.e. 9-hydroxy-alpha-lapachone, NPLC519, noncompetitive, significant activity in the inhibition of Helicobacter pylori strain SS1 growth with MIC of 2.5 mg/ml Helicobacter pylori

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.02
-
O-succinyl-L-homoserine 25°C, pH 9.0 Helicobacter pylori

Organism

Organism UniProt Comment Textmining
Helicobacter pylori Q1M0P5
-
-
Helicobacter pylori SS Q1M0P5
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Helicobacter pylori

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.403
-
25°C, pH 9.0 Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-succinyl-L-homoserine + H2O
-
Helicobacter pylori succinate + 2-oxobutyrate + NH3
-
?
O-succinyl-L-homoserine + H2O
-
Helicobacter pylori SS succinate + 2-oxobutyrate + NH3
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
Helicobacter pylori

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.297
-
O-succinyl-L-homoserine 25°C, pH 9.0 Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Helicobacter pylori

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.016
-
6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione 25°C, pH 9.0 Helicobacter pylori
0.019
-
2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione 25°C, pH 9.0 Helicobacter pylori
0.031
-
(1S,3aS,4S,6aS)-1,4-di(3,4,5-trimethoxy)-phenyloctahydropentalene 25°C, pH 9.0 Helicobacter pylori
0.06
-
(1S,3aS,4R,6aR)-1,4-bis(1,3-benzodioxol-5-yl)hexahydropentalen-3a(1H)-ol 25°C, pH 9.0 Helicobacter pylori

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009
-
25°C, pH 9.0 Helicobacter pylori 6-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
0.011
-
25°C, pH 9.0 Helicobacter pylori 2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
0.019
-
25°C, pH 9.0 Helicobacter pylori (1S,3aS,4R,6aR)-1,4-bis(1,3-benzodioxol-5-yl)hexahydropentalen-3a(1H)-ol
0.027
-
25°C, pH 9.0 Helicobacter pylori (1S,3aS,4S,6aS)-1,4-di(3,4,5-trimethoxy)-phenyloctahydropentalene