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Literature summary for 2.5.1.47 extracted from

  • Shibagaki, N.; Grossman, A.R.
    Binding of cysteine synthase to the STAS domain of sulfate transporter and its regulatory consequences (2010), J. Biol. Chem., 285, 25094-25102.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm root plasma membrane SO42- transporter SULTR1,2 physically interacts with the enzyme. The domain of SULTR1,2 important for association with enzyme is called the STAS domain, located at the C-terminus of the transporter and extending from the plasma membrane into the cytoplasm. The binding of enzyme to the STAS domain negatively impacts transporter activity. In contrast, the activity of purified enzyme measured in vitro is enhanced by co-incubation with the STAS domain of SULTR1,2 but not with the analogous domain of the SO42- transporter isoform SULTR1,1. The observations suggest a regulatory model in which interactions between SULTR1,2 and enzyme coordinate internalization of SO42- with the energetic/metabolic state of plant root cells Arabidopsis thaliana 5737
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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Source Tissue

Source Tissue Comment Organism Textmining
root root plasma membrane SO42- transporter SULTR1,2 physically interacts with the enzyme Arabidopsis thaliana
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General Information

General Information Comment Organism
physiological function root plasma membrane SO42- transporter SULTR1,2 physically interacts with the enzyme. The domain of SULTR1,2 important for association with enzyme is called the STAS domain, located at the C-terminus of the transporter and extending from the plasma membrane into the cytoplasm. The binding of enzyme to the STAS domain negatively impacts transporter activity. In contrast, the activity of purified enzyme measured in vitro is enhanced by co-incubation with the STAS domain of SULTR1,2 but not with the analogous domain of the SO42- transporter isoform SULTR1,1. The observations suggest a regulatory model in which interactions between SULTR1,2 and enzyme coordinate internalization of SO42- with the energetic/metabolic state of plant root cells Arabidopsis thaliana