Literature summary for 2.5.1.29 extracted from

Breitenbach, J.; Visser, H.; Verdoes, J.C.; van Ooyen, A.J.; Sandmann, G.
Engineering of geranylgeranyl pyrophosphate synthase levels and physiological conditions for enhanced carotenoid and astaxanthin synthesis in Xanthophyllomyces dendrorhous (2011), Biotechnol. Lett., 33, 755-761.

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Application

Application	Comment	Organism
food industry	the enzyme in Xanthophyllomyces is used for production of astaxanthin, i.e. 3,3'-hydroxy-4,4'-diketo-beta-carotene, which is an industrially important carotenoid used for feeding salmon or trout in farming	Phaffia rhodozyma
synthesis	the enzyme in Xanthophyllomyces is used for production of astaxanthin, i.e. 3,3'-hydroxy-4,4'-diketo-beta-carotene, which is an industrially important carotenoid used for feeding salmon or trout in farming	Phaffia rhodozyma

Cloned(Commentary)

Cloned (Comment)	Organism
gene crtE, DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli, overexpression in transgenic Xanthophyllomyces dendrorhous	Phaffia rhodozyma

Protein Variants

Protein Variants	Comment	Organism
additional information	engineering of Xanthophyllomyces dendrorhous by transforming it with the crtE cDNA to divert metabolite flow from the sterol pathway towards carotenoid biosynthesis. Transformants show increased levels of geranylgeranyl diphosphate synthase leading to higher carotenoid levels including astaxanthin by 8fold	Phaffia rhodozyma

Organism

Organism	UniProt	Comment	Textmining
Phaffia rhodozyma	-	a basidiomycetous yeast, the sexual state of Phaffia rhodozyma, gene crtE	-
Phaffia rhodozyma CBS6938, ATCC 96594	-	a basidiomycetous yeast, the sexual state of Phaffia rhodozyma, gene crtE	-

Synonyms

Synonyms	Comment	Organism
CrtE	-	Phaffia rhodozyma
geranylgeranyl pyrophosphate synthase	-	Phaffia rhodozyma
GGPP synthase	-	Phaffia rhodozyma

General Information

General Information	Comment	Organism
metabolism	CrtE catalyzes one of the first steps in the carotenogenic pathway, overview	Phaffia rhodozyma

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Release 2023.1 (January 2023)