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Literature summary for 2.5.1.22 extracted from

  • Peng, Y.; Norris, J.; Schwartz, C.; Alexov, E.
    Revealing the effects of missense mutations causing Snyder-Robinson syndrome on the stability and dimerization of spermine synthase (2016), Int. J. Mol. Sci., 17, 77.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
F58L the mutation is associated with the Snyder-Robinson syndrome Homo sapiens
G56S the mutation is associated with the Snyder-Robinson syndrome Homo sapiens
G67E the mutation is associated with the Snyder-Robinson syndrome Homo sapiens
M35R the mutation is associated with the Snyder-Robinson syndrome Homo sapiens
P112L the mutation is associated with the Snyder-Robinson syndrome Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl 3-(methylthio)propylamine + spermidine Homo sapiens
-
S-methyl-5'-thioadenosine + spermine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52788
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphoblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl 3-(methylthio)propylamine + spermidine
-
Homo sapiens S-methyl-5'-thioadenosine + spermine
-
?

Subunits

Subunits Comment Organism
homodimer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
SpmSyn
-
Homo sapiens