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Literature summary for 2.5.1.21 extracted from

  • Macias-Alonso, M.; Andres, L.S.; Cordova-Guerrero, I.; Estolano-Cobian, A.; Diaz-Rubio, L.; Marrero, J.G.
    Inhibition of squalene synthase of rat liver by abietane diterpenes derivatives (2019), Nat. Prod. Res., 35, 2972-2976.
    View publication on PubMed
Search for more literature for 2.5.1.21

Inhibitors

Inhibitors Comment Organism Structure
11,12-di-O-methylcarnosol
-
 Rattus norvegicus
11,12-diacetyl-carnosol
-
 Rattus norvegicus
7alpha-ethoxyrosmanol
-
 Rattus norvegicus
7alpha-methoxyrosmanol
-
 Rattus norvegicus
carnosol
-
 Rattus norvegicus
carnosol quinone
-
 Rattus norvegicus
galdosol
-
 Rattus norvegicus
isorosmanol
-
 Rattus norvegicus
rosmadial
-
 Rattus norvegicus
rosmanol
-
 Rattus norvegicus
rosmaquinone
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q02769
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
SQS
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0176
-
 pH 7.4, 37°C Rattus norvegicus carnosol
0.0184
-
 pH 7.4, 37°C Rattus norvegicus 11,12-di-O-methylcarnosol
0.0269
-
 pH 7.4, 37°C Rattus norvegicus rosmaquinone
0.0692
-
 pH 7.4, 37°C Rattus norvegicus galdosol
0.0802
-
 pH 7.4, 37°C Rattus norvegicus rosmanol
0.0903
-
 pH 7.4, 37°C Rattus norvegicus isorosmanol
0.0969
-
 pH 7.4, 37°C Rattus norvegicus rosmadial
0.378
-
 pH 7.4, 37°C Rattus norvegicus 11,12-diacetyl-carnosol
0.543
-
 pH 7.4, 37°C Rattus norvegicus 7alpha-methoxyrosmanol
1.336
-
 pH 7.4, 37°C Rattus norvegicus 7alpha-ethoxyrosmanol
1.524
-
 pH 7.4, 37°C Rattus norvegicus carnosol quinone