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Literature summary for 2.5.1.21 extracted from

  • Sanchita, S.; Singh, G.; Sharma, A.
    In silico study of binding motifs in squalene synthase enzyme of secondary metabolic pathway of Solanaceae [corrected] (2014), Mol. Biol. Rep., 41, 7201-7208.
    View publication on PubMed
Search for more literature for 2.5.1.21

Cloned(Commentary)

Cloned (Comment) Organism
two genes SQS, DA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis Withania somnifera

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum associated enzyme with C-terminus anchored in the endoplasmic reticulum membrane and the N-terminus including active site is exposed in the cytosol Withania somnifera 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Withania somnifera

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ Withania somnifera
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 squalene + 2 diphosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Withania somnifera H9L9T8 two genes
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate + NADPH + H+
-
 Withania somnifera squalene + 2 diphosphate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
SQS
-
 Withania somnifera

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Withania somnifera

General Information

General Information Comment Organism
additional information homology modelling of SQS enzyme of Withania somnifera for the prediction of three-dimensional structure, molecular docking study of considered substrates, overview Withania somnifera
physiological function SQS play an important regulatory role in phytosterol biosynthetic pathway Withania somnifera