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Literature summary for 2.5.1.21 extracted from

  • Saito, K.; Shirasago, Y.; Suzuki, T.; Aizaki, H.; Hanada, K.; Wakita, T.; Nishijima, M.; Fukasawa, M.
    Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus (2015), J. Virol., 89, 2220-2232.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development enzyme SQS is a potential target for antiviral strategies against hepatitis C virus Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene FDFT1, quantitative reverse transcription-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information siRNA-mediated knockdown of SQS in hepatoma cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
YM-53601
-
 Homo sapiens
zaragozic acid A
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P37268 gene FDFT1
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
-
 Homo sapiens
-
Huh-7.5.1 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
SQS
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the SQS inhibitors YM-53601 and zaragozic acid A decrease hepatitis C virus RNA, protein, and progeny production in HCV-infected cells without affecting cell viability, using the HCV JFH-1 strain and human hepatoma Huh-7.5.1-derived cells. siRNA-mediated knockdown of SQS leads to significantly reduced HCV production, confirming the enzyme acts as an antiviral target. A metabolic labeling study demonstrates that enzyme inhibitor YM-53601 suppresses the biosynthesis of cholesterol and cholesteryl esters at antiviral concentrations Homo sapiens