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BRENDA support

Literature summary for 2.5.1.21 extracted from

  • Calo, F.; Bondke, A.; Richardson, J.; White, A.; Barrett, A.
    Total synthesis and determination of the absolute stereochemistry of the squalene synthase inhibitors CJ-13,981 and CJ-13,982 (2009), Tetrahedron Lett., 50, 3388-3390.
No PubMed abstract available

Application

Application Comment Organism
medicine attractive target for pharmaceutical discovery in treatment of hypercholestermiae Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-C-carboxy-2,4-dideoxy-2-dodec-11-en-1-ylpentaric acid
-
Homo sapiens
3-C-carboxy-2,4-dideoxy-2-dodecylpentaric acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
squalene synthase
-
Homo sapiens
SSase
-
Homo sapiens

General Information

General Information Comment Organism
metabolism key enzyme in the isoprenoid pathway Homo sapiens