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Literature summary for 2.5.1.21 extracted from

  • Do, R.; Kiss, R.S.; Gaudet, D.; Engert, J.C.
    Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway (2009), Clin. Genet., 75, 19-29.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K45R mutation with influence on total cholesterol and non-HDL-C levels Cavia porcellus
K45R mutation with influence on total cholesterol and non-HDL-C levels Mus musculus
K45R mutation with influence on total cholesterol and non-HDL-C levels Homo sapiens
K45R mutation with influence on total cholesterol and non-HDL-C levels Oryctolagus cuniculus
K45R mutation with influence on total cholesterol and non-HDL-C levels Macaca mulatta

Inhibitors

Inhibitors Comment Organism Structure
atorvastatin
-
Homo sapiens
BMS-188494
-
Homo sapiens
RPR107393
-
Homo sapiens
RPR107393 inhibition of cholesterol biosynthesis and reduced plasma total cholesterol levels Rattus norvegicus
T-91485
-
Homo sapiens
TAK-475
-
Homo sapiens
TAK-475
-
Mus musculus
TAK-475
-
Oryctolagus cuniculus
YM-53601 reduction of non-high-density lipoprotein cholesterol concentrations Cavia porcellus
YM-53601 reduction of non-high-density lipoprotein cholesterol concentrations Macaca mulatta
zaragozic acid
-
Homo sapiens
zaragozic acid decrease in plasma cholesterol Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Cavia porcellus 5783
-
endoplasmic reticulum
-
Mus musculus 5783
-
endoplasmic reticulum
-
Homo sapiens 5783
-
endoplasmic reticulum
-
Rattus norvegicus 5783
-
endoplasmic reticulum
-
Oryctolagus cuniculus 5783
-
endoplasmic reticulum
-
Macaca mulatta 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ cofactor Cavia porcellus
Mg2+ cofactor Mus musculus
Mg2+ cofactor Homo sapiens
Mg2+ cofactor Rattus norvegicus
Mg2+ cofactor Oryctolagus cuniculus
Mg2+ cofactor Macaca mulatta

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 farnesyl diphosphate Cavia porcellus
-
presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate Mus musculus
-
presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate Homo sapiens
-
presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate Rattus norvegicus
-
presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate Oryctolagus cuniculus
-
presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate Macaca mulatta
-
presqualene diphosphate + diphosphate
-
?
presqualene diphosphate + NAD(P)H + H+ Cavia porcellus
-
squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+ Mus musculus
-
squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+ Homo sapiens
-
squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+ Rattus norvegicus
-
squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+ Macaca mulatta
-
squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NADPH + H+ Oryctolagus cuniculus
-
squalene + diphosphate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-
Macaca mulatta
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 farnesyl diphosphate
-
Cavia porcellus presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate
-
Mus musculus presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate
-
Homo sapiens presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate
-
Rattus norvegicus presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate
-
Oryctolagus cuniculus presqualene diphosphate + diphosphate
-
?
2 farnesyl diphosphate
-
Macaca mulatta presqualene diphosphate + diphosphate
-
?
presqualene diphosphate + NAD(P)H + H+
-
Cavia porcellus squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+
-
Mus musculus squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+
-
Homo sapiens squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+
-
Rattus norvegicus squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NAD(P)H + H+
-
Macaca mulatta squalene + diphosphate + NAD(P)+
-
?
presqualene diphosphate + NADPH + H+
-
Oryctolagus cuniculus squalene + diphosphate + NADP+
-
?

Synonyms

Synonyms Comment Organism
farnesyldiphosphate farnesyltransferase 1
-
Cavia porcellus
farnesyldiphosphate farnesyltransferase 1
-
Mus musculus
farnesyldiphosphate farnesyltransferase 1
-
Homo sapiens
farnesyldiphosphate farnesyltransferase 1
-
Rattus norvegicus
farnesyldiphosphate farnesyltransferase 1
-
Oryctolagus cuniculus
farnesyldiphosphate farnesyltransferase 1
-
Macaca mulatta
FDFT1
-
Cavia porcellus
FDFT1
-
Mus musculus
FDFT1
-
Homo sapiens
FDFT1
-
Rattus norvegicus
FDFT1
-
Oryctolagus cuniculus
FDFT1
-
Macaca mulatta
squalene synthase
-
Cavia porcellus
squalene synthase
-
Mus musculus
squalene synthase
-
Homo sapiens
squalene synthase
-
Rattus norvegicus
squalene synthase
-
Oryctolagus cuniculus
squalene synthase
-
Macaca mulatta

General Information

General Information Comment Organism
metabolism part of cholesterol biosynthesis pathway Cavia porcellus
metabolism part of cholesterol biosynthesis pathway Mus musculus
metabolism part of cholesterol biosynthesis pathway Homo sapiens
metabolism part of cholesterol biosynthesis pathway Rattus norvegicus
metabolism part of cholesterol biosynthesis pathway Oryctolagus cuniculus
metabolism part of cholesterol biosynthesis pathway Macaca mulatta
physiological function essential role in embryonic development Mus musculus