Protein Variants | Comment | Organism |
---|---|---|
K45R | mutation with influence on total cholesterol and non-HDL-C levels | Cavia porcellus |
K45R | mutation with influence on total cholesterol and non-HDL-C levels | Mus musculus |
K45R | mutation with influence on total cholesterol and non-HDL-C levels | Homo sapiens |
K45R | mutation with influence on total cholesterol and non-HDL-C levels | Oryctolagus cuniculus |
K45R | mutation with influence on total cholesterol and non-HDL-C levels | Macaca mulatta |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
atorvastatin | - |
Homo sapiens | |
BMS-188494 | - |
Homo sapiens | |
RPR107393 | - |
Homo sapiens | |
RPR107393 | inhibition of cholesterol biosynthesis and reduced plasma total cholesterol levels | Rattus norvegicus | |
T-91485 | - |
Homo sapiens | |
TAK-475 | - |
Homo sapiens | |
TAK-475 | - |
Mus musculus | |
TAK-475 | - |
Oryctolagus cuniculus | |
YM-53601 | reduction of non-high-density lipoprotein cholesterol concentrations | Cavia porcellus | |
YM-53601 | reduction of non-high-density lipoprotein cholesterol concentrations | Macaca mulatta | |
zaragozic acid | - |
Homo sapiens | |
zaragozic acid | decrease in plasma cholesterol | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Cavia porcellus | 5783 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
endoplasmic reticulum | - |
Oryctolagus cuniculus | 5783 | - |
endoplasmic reticulum | - |
Macaca mulatta | 5783 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | cofactor | Cavia porcellus | |
Mg2+ | cofactor | Mus musculus | |
Mg2+ | cofactor | Homo sapiens | |
Mg2+ | cofactor | Rattus norvegicus | |
Mg2+ | cofactor | Oryctolagus cuniculus | |
Mg2+ | cofactor | Macaca mulatta |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 farnesyl diphosphate | Cavia porcellus | - |
presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | Mus musculus | - |
presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | Homo sapiens | - |
presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | Rattus norvegicus | - |
presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | Oryctolagus cuniculus | - |
presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | Macaca mulatta | - |
presqualene diphosphate + diphosphate | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | Cavia porcellus | - |
squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | Mus musculus | - |
squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | Homo sapiens | - |
squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | Rattus norvegicus | - |
squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | Macaca mulatta | - |
squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NADPH + H+ | Oryctolagus cuniculus | - |
squalene + diphosphate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Macaca mulatta | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 farnesyl diphosphate | - |
Cavia porcellus | presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | - |
Mus musculus | presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | - |
Homo sapiens | presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | - |
Rattus norvegicus | presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | - |
Oryctolagus cuniculus | presqualene diphosphate + diphosphate | - |
? | |
2 farnesyl diphosphate | - |
Macaca mulatta | presqualene diphosphate + diphosphate | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | - |
Cavia porcellus | squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | - |
Mus musculus | squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | - |
Homo sapiens | squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | - |
Rattus norvegicus | squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NAD(P)H + H+ | - |
Macaca mulatta | squalene + diphosphate + NAD(P)+ | - |
? | |
presqualene diphosphate + NADPH + H+ | - |
Oryctolagus cuniculus | squalene + diphosphate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
farnesyldiphosphate farnesyltransferase 1 | - |
Cavia porcellus |
farnesyldiphosphate farnesyltransferase 1 | - |
Mus musculus |
farnesyldiphosphate farnesyltransferase 1 | - |
Homo sapiens |
farnesyldiphosphate farnesyltransferase 1 | - |
Rattus norvegicus |
farnesyldiphosphate farnesyltransferase 1 | - |
Oryctolagus cuniculus |
farnesyldiphosphate farnesyltransferase 1 | - |
Macaca mulatta |
FDFT1 | - |
Cavia porcellus |
FDFT1 | - |
Mus musculus |
FDFT1 | - |
Homo sapiens |
FDFT1 | - |
Rattus norvegicus |
FDFT1 | - |
Oryctolagus cuniculus |
FDFT1 | - |
Macaca mulatta |
squalene synthase | - |
Cavia porcellus |
squalene synthase | - |
Mus musculus |
squalene synthase | - |
Homo sapiens |
squalene synthase | - |
Rattus norvegicus |
squalene synthase | - |
Oryctolagus cuniculus |
squalene synthase | - |
Macaca mulatta |
General Information | Comment | Organism |
---|---|---|
metabolism | part of cholesterol biosynthesis pathway | Cavia porcellus |
metabolism | part of cholesterol biosynthesis pathway | Mus musculus |
metabolism | part of cholesterol biosynthesis pathway | Homo sapiens |
metabolism | part of cholesterol biosynthesis pathway | Rattus norvegicus |
metabolism | part of cholesterol biosynthesis pathway | Oryctolagus cuniculus |
metabolism | part of cholesterol biosynthesis pathway | Macaca mulatta |
physiological function | essential role in embryonic development | Mus musculus |