Application | Comment | Organism |
---|---|---|
medicine | aim of inhibitors in treatment of hypercholesterolemia | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BMS 187745 | decrease of cholesterol or LDL | Homo sapiens | |
BMS-188494 | decrease of cholesterol or LDL | Homo sapiens | |
BMS-188494 | no induction of myotoxicity | Rattus norvegicus | |
EP2302 | decrease of cholesterol or LDL | Homo sapiens | |
EP2302 | decrease of cholesterol and triglyceride biosynthesis | Oryctolagus cuniculus | |
EP2306 | decrease of cholesterol or LDL | Homo sapiens | |
EP2306 | decrease of cholesterol and triglyceride biosynthesis | Oryctolagus cuniculus | |
ER-27856 | decrease of cholesterol biosynthesis | Macaca sp. | |
ER-27856 | decrease of cholesterol biosynthesis | Rattus norvegicus | |
ER-28448 | decrease of cholesterol biosynthesis | Macaca sp. | |
ER-28448 | decrease of cholesterol biosynthesis | Rattus norvegicus | |
fenofibrate | - |
Cricetus cricetus | |
lapaquistat | lipid-lowering effect | Callithrix sp. | |
lapaquistat | lipid-lowering effect | Canis lupus familiaris | |
lapaquistat | decrease of cholesterol or LDL | Homo sapiens | |
lapaquistat | lipid-lowering effect | Macaca sp. | |
lapaquistat | lipid-lowering effect | Rattus norvegicus | |
RPR107393 | reduction in plasma cholesterol concentrations | Callithrix sp. | |
RPR107393 | reduction of plasman cholesterol concentrations | Rattus norvegicus | |
squalestatin | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Canis lupus familiaris | |
squalestatin | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Rattus norvegicus | |
YM-53601 | decrease of non-high-density lipoprotein cholesterol | Cavia porcellus | |
YM-53601 | decrease of non-high-density lipoprotein cholesterol | Cricetus cricetus | |
YM-53601 | decrease of non-high-density lipoprotein cholesterol | Macaca sp. | |
zaragozic acid | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Canis lupus familiaris | |
zaragozic acid | hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Cavia porcellus | 5783 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
endoplasmic reticulum | - |
Oryctolagus cuniculus | 5783 | - |
endoplasmic reticulum | - |
Canis lupus familiaris | 5783 | - |
endoplasmic reticulum | - |
Callithrix sp. | 5783 | - |
endoplasmic reticulum | - |
Cricetus cricetus | 5783 | - |
endoplasmic reticulum | - |
Macaca sp. | 5783 | - |
peroxisome | - |
Cavia porcellus | 5777 | - |
peroxisome | - |
Mus musculus | 5777 | - |
peroxisome | - |
Homo sapiens | 5777 | - |
peroxisome | - |
Rattus norvegicus | 5777 | - |
peroxisome | - |
Oryctolagus cuniculus | 5777 | - |
peroxisome | - |
Canis lupus familiaris | 5777 | - |
peroxisome | - |
Callithrix sp. | 5777 | - |
peroxisome | - |
Cricetus cricetus | 5777 | - |
peroxisome | - |
Macaca sp. | 5777 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | cofactor | Cavia porcellus | |
Mg2+ | cofactor | Mus musculus | |
Mg2+ | cofactor | Homo sapiens | |
Mg2+ | cofactor | Rattus norvegicus | |
Mg2+ | cofactor | Oryctolagus cuniculus | |
Mg2+ | cofactor | Canis lupus familiaris | |
Mg2+ | cofactor | Callithrix sp. | |
Mg2+ | cofactor | Cricetus cricetus | |
Mg2+ | cofactor | Macaca sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Callithrix sp. | - |
- |
- |
Canis lupus familiaris | - |
- |
- |
Cavia porcellus | - |
- |
- |
Cricetus cricetus | - |
- |
- |
Homo sapiens | - |
- |
- |
Macaca sp. | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Cavia porcellus | - |
hepatocyte | - |
Mus musculus | - |
hepatocyte | - |
Homo sapiens | - |
hepatocyte | - |
Rattus norvegicus | - |
hepatocyte | - |
Oryctolagus cuniculus | - |
hepatocyte | - |
Canis lupus familiaris | - |
hepatocyte | - |
Callithrix sp. | - |
hepatocyte | - |
Cricetus cricetus | - |
hepatocyte | - |
Macaca sp. | - |
Synonyms | Comment | Organism |
---|---|---|
squalene synthase | - |
Cavia porcellus |
squalene synthase | - |
Mus musculus |
squalene synthase | - |
Homo sapiens |
squalene synthase | - |
Rattus norvegicus |
squalene synthase | - |
Oryctolagus cuniculus |
squalene synthase | - |
Canis lupus familiaris |
squalene synthase | - |
Callithrix sp. |
squalene synthase | - |
Cricetus cricetus |
squalene synthase | - |
Macaca sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Cavia porcellus | |
NADH | - |
Mus musculus | |
NADH | - |
Homo sapiens | |
NADH | - |
Rattus norvegicus | |
NADH | - |
Oryctolagus cuniculus | |
NADH | - |
Canis lupus familiaris | |
NADH | - |
Callithrix sp. | |
NADH | - |
Cricetus cricetus | |
NADH | - |
Macaca sp. | |
NADPH | - |
Cavia porcellus | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Oryctolagus cuniculus | |
NADPH | - |
Canis lupus familiaris | |
NADPH | - |
Callithrix sp. | |
NADPH | - |
Cricetus cricetus | |
NADPH | - |
Macaca sp. |
General Information | Comment | Organism |
---|---|---|
metabolism | part of cholesterol synthesis pathway | Cavia porcellus |
metabolism | part of cholesterol synthesis pathway | Mus musculus |
metabolism | part of cholesterol synthesis pathway | Homo sapiens |
metabolism | part of cholesterol synthesis pathway | Rattus norvegicus |
metabolism | part of cholesterol synthesis pathway | Oryctolagus cuniculus |
metabolism | part of cholesterol synthesis pathway | Canis lupus familiaris |
metabolism | part of cholesterol synthesis pathway | Callithrix sp. |
metabolism | part of cholesterol synthesis pathway | Cricetus cricetus |
metabolism | part of cholesterol synthesis pathway | Macaca sp. |
physiological function | influence on regulation of cholesterol metabolism | Cavia porcellus |
physiological function | influence on regulation of cholesterol metabolism | Mus musculus |
physiological function | influence on regulation of cholesterol metabolism | Rattus norvegicus |
physiological function | influence on regulation of cholesterol metabolism | Oryctolagus cuniculus |
physiological function | influence on regulation of cholesterol metabolism | Canis lupus familiaris |
physiological function | influence on regulation of cholesterol metabolism | Callithrix sp. |
physiological function | influence on regulation of cholesterol metabolism | Cricetus cricetus |
physiological function | influence on regulation of cholesterol metabolism | Macaca sp. |