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Literature summary for 2.5.1.21 extracted from

  • Seiki, S.; Frishman, W.H.
    Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia (2009), Cardiol. Rev., 17, 70-76.
    View publication on PubMed

Application

Application Comment Organism
medicine aim of inhibitors in treatment of hypercholesterolemia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BMS 187745 decrease of cholesterol or LDL Homo sapiens
BMS-188494 decrease of cholesterol or LDL Homo sapiens
BMS-188494 no induction of myotoxicity Rattus norvegicus
EP2302 decrease of cholesterol or LDL Homo sapiens
EP2302 decrease of cholesterol and triglyceride biosynthesis Oryctolagus cuniculus
EP2306 decrease of cholesterol or LDL Homo sapiens
EP2306 decrease of cholesterol and triglyceride biosynthesis Oryctolagus cuniculus
ER-27856 decrease of cholesterol biosynthesis Macaca sp.
ER-27856 decrease of cholesterol biosynthesis Rattus norvegicus
ER-28448 decrease of cholesterol biosynthesis Macaca sp.
ER-28448 decrease of cholesterol biosynthesis Rattus norvegicus
fenofibrate
-
Cricetus cricetus
lapaquistat lipid-lowering effect Callithrix sp.
lapaquistat lipid-lowering effect Canis lupus familiaris
lapaquistat decrease of cholesterol or LDL Homo sapiens
lapaquistat lipid-lowering effect Macaca sp.
lapaquistat lipid-lowering effect Rattus norvegicus
RPR107393 reduction in plasma cholesterol concentrations Callithrix sp.
RPR107393 reduction of plasman cholesterol concentrations Rattus norvegicus
squalestatin hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid Canis lupus familiaris
squalestatin hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid Rattus norvegicus
YM-53601 decrease of non-high-density lipoprotein cholesterol Cavia porcellus
YM-53601 decrease of non-high-density lipoprotein cholesterol Cricetus cricetus
YM-53601 decrease of non-high-density lipoprotein cholesterol Macaca sp.
zaragozic acid hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid Canis lupus familiaris
zaragozic acid hypolipidemic effects but potential toxicity because of high levels of urinary dicarboxylic acid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Cavia porcellus 5783
-
endoplasmic reticulum
-
Mus musculus 5783
-
endoplasmic reticulum
-
Homo sapiens 5783
-
endoplasmic reticulum
-
Rattus norvegicus 5783
-
endoplasmic reticulum
-
Oryctolagus cuniculus 5783
-
endoplasmic reticulum
-
Canis lupus familiaris 5783
-
endoplasmic reticulum
-
Callithrix sp. 5783
-
endoplasmic reticulum
-
Cricetus cricetus 5783
-
endoplasmic reticulum
-
Macaca sp. 5783
-
peroxisome
-
Cavia porcellus 5777
-
peroxisome
-
Mus musculus 5777
-
peroxisome
-
Homo sapiens 5777
-
peroxisome
-
Rattus norvegicus 5777
-
peroxisome
-
Oryctolagus cuniculus 5777
-
peroxisome
-
Canis lupus familiaris 5777
-
peroxisome
-
Callithrix sp. 5777
-
peroxisome
-
Cricetus cricetus 5777
-
peroxisome
-
Macaca sp. 5777
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ cofactor Cavia porcellus
Mg2+ cofactor Mus musculus
Mg2+ cofactor Homo sapiens
Mg2+ cofactor Rattus norvegicus
Mg2+ cofactor Oryctolagus cuniculus
Mg2+ cofactor Canis lupus familiaris
Mg2+ cofactor Callithrix sp.
Mg2+ cofactor Cricetus cricetus
Mg2+ cofactor Macaca sp.

Organism

Organism UniProt Comment Textmining
Callithrix sp.
-
-
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Cricetus cricetus
-
-
-
Homo sapiens
-
-
-
Macaca sp.
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Cavia porcellus
-
hepatocyte
-
Mus musculus
-
hepatocyte
-
Homo sapiens
-
hepatocyte
-
Rattus norvegicus
-
hepatocyte
-
Oryctolagus cuniculus
-
hepatocyte
-
Canis lupus familiaris
-
hepatocyte
-
Callithrix sp.
-
hepatocyte
-
Cricetus cricetus
-
hepatocyte
-
Macaca sp.
-

Synonyms

Synonyms Comment Organism
squalene synthase
-
Cavia porcellus
squalene synthase
-
Mus musculus
squalene synthase
-
Homo sapiens
squalene synthase
-
Rattus norvegicus
squalene synthase
-
Oryctolagus cuniculus
squalene synthase
-
Canis lupus familiaris
squalene synthase
-
Callithrix sp.
squalene synthase
-
Cricetus cricetus
squalene synthase
-
Macaca sp.

Cofactor

Cofactor Comment Organism Structure
NADH
-
Cavia porcellus
NADH
-
Mus musculus
NADH
-
Homo sapiens
NADH
-
Rattus norvegicus
NADH
-
Oryctolagus cuniculus
NADH
-
Canis lupus familiaris
NADH
-
Callithrix sp.
NADH
-
Cricetus cricetus
NADH
-
Macaca sp.
NADPH
-
Cavia porcellus
NADPH
-
Mus musculus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
NADPH
-
Oryctolagus cuniculus
NADPH
-
Canis lupus familiaris
NADPH
-
Callithrix sp.
NADPH
-
Cricetus cricetus
NADPH
-
Macaca sp.

General Information

General Information Comment Organism
metabolism part of cholesterol synthesis pathway Cavia porcellus
metabolism part of cholesterol synthesis pathway Mus musculus
metabolism part of cholesterol synthesis pathway Homo sapiens
metabolism part of cholesterol synthesis pathway Rattus norvegicus
metabolism part of cholesterol synthesis pathway Oryctolagus cuniculus
metabolism part of cholesterol synthesis pathway Canis lupus familiaris
metabolism part of cholesterol synthesis pathway Callithrix sp.
metabolism part of cholesterol synthesis pathway Cricetus cricetus
metabolism part of cholesterol synthesis pathway Macaca sp.
physiological function influence on regulation of cholesterol metabolism Cavia porcellus
physiological function influence on regulation of cholesterol metabolism Mus musculus
physiological function influence on regulation of cholesterol metabolism Rattus norvegicus
physiological function influence on regulation of cholesterol metabolism Oryctolagus cuniculus
physiological function influence on regulation of cholesterol metabolism Canis lupus familiaris
physiological function influence on regulation of cholesterol metabolism Callithrix sp.
physiological function influence on regulation of cholesterol metabolism Cricetus cricetus
physiological function influence on regulation of cholesterol metabolism Macaca sp.