Literature summary for 2.5.1.21 extracted from

Orenes Lorente, S.; Gomez, R.; Jimenez, C.; Cammerer, S.; Yardley, V.; de Luca-Fradley, K.; Croft, S.L.; Ruiz Perez, L.M.; Urbina, J.; Gonzalez Pacanowska, D.; Gilbert, I.H.
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa (2005), Bioorg. Med. Chem., 13, 3519-3529.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-(biphenyl-4-yl)-2,3-dehydroquinuclidine	50% inhibition at 243 nM	Leishmania major
3-(biphenyl-4-yl)-3-hydroxyquinuclidine	50% inhibition at 13 nM	Leishmania major
3-(biphenyl-4-yl)-4'[(t-butyldimethylsilyl)oxy]-3-hydroxyquinuclidine	50% inhibition above 0.001 mM	Leishmania major
3-(biphenyl-4-yl-4'-hydroxy)-2,3-dehydroquinuclidine	50% inhibition at 96 nM	Leishmania major

Organism

Organism	UniProt	Comment	Textmining
Leishmania major	-	recombinant enzyme	-

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Release 2023.1 (January 2023)