Literature summary for 2.5.1.21 extracted from

McKenzie, T.L.; Jiang, G.; Straubhaar, J.R.; Conrad, D.G.; Shechter, I.
Molecular cloning, expression, and characterization of the cDNA for the rat hepatic squalene synthase (1992), J. Biol. Chem., 267, 21368-21374.

Search for more literature for 2.5.1.21

Cloned(Commentary)

Cloned (Comment)	Organism
enzyme expressed in Escherichia coli	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	model of the secondary structure and its possible membrane orientation	Rattus norvegicus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
farnesyl diphosphate + farnesyl diphosphate	Rattus norvegicus	squalene is the first sterol intermediate in cholesterol biosynthesis	diphosphate + presqualene diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	expressed in Escherichia coli	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + farnesyl diphosphate	-	Rattus norvegicus	diphosphate + presqualene diphosphate	-	?
farnesyl diphosphate + farnesyl diphosphate	squalene is the first sterol intermediate in cholesterol biosynthesis	Rattus norvegicus	diphosphate + presqualene diphosphate	-	?
presqualene diphosphate + NAD(P)H	-	Rattus norvegicus	squalene + NAD(P)+ + diphosphate	-	?

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Release 2023.1 (January 2023)