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Literature summary for 2.5.1.21 extracted from
- Investigations of substrate specificity of squalene synthase (1977), Tetrahedron Lett., 18, 1555-1558.
No PubMed abstract available
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (E,E)-7-desmethylfarnesyl diphosphate + NADPH | at 60% of the efficiency that farnesyl diphosphate is converted to squalene | Saccharomyces cerevisiae | 6,19-didesmethylsqualene + NADP+ + diphosphate | in absence of farnesyl diphosphate, 6-desmethylsqualene is produced in presence of farnesyl diphosphate | ? |  |
| 10,11-dihydrofarnesyl diphosphate + NADPH | at 60% of the efficiency that farnesyl diphosphate is converted to squalene | Saccharomyces cerevisiae | 2,3,22,23-tetrahydrosqualene + NADP+ + diphosphate | - |
? | |
| farnesyl diphosphate + NAD(P)H | - |
Saccharomyces cerevisiae | squalene + diphosphate + NAD(P)+ | - |
? | |
| additional information | specificity overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | no substrate: 6,7-dihydrofarnesyl diphosphate, 3-desmethylfarnesyl diphosphate | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | not metabolized: (E)-6,7,10,11-tetrahydrofarnesyl diphosphate | Saccharomyces cerevisiae | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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