Inhibitors | Comment | Organism | Structure |
---|---|---|---|
farnesyl diphosphate | substrate inhibitor of squalene synthase reaction | Saccharomyces cerevisiae | |
NADP+ | inhibitor of squalene synthesis | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
NADPH | - |
Saccharomyces cerevisiae | |
0.004 | - |
NADH | - |
Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
47000 | - |
x * 47000, SDS-PAGE | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.816 | - |
presqualene | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + NADH + H+ | - |
Saccharomyces cerevisiae | squalene + diphosphate + NAD+ | - |
? | |
farnesyl diphosphate + farnesyl diphosphate | - |
Saccharomyces cerevisiae | diphosphate + presqualene diphosphate | - |
? | |
farnesyl diphosphate + NAD(P)H | - |
Saccharomyces cerevisiae | squalene + diphosphate + NAD(P)+ | presqualene diphosphate and squalene are produced in a ratio of 6:1 | ? | |
presqualene diphosphate + NAD(P)H | one protein with 2 catalytic sites may be involved in synthesis of presqualene diphosphate and for its reduction to squalene | Saccharomyces cerevisiae | squalene + NAD(P)+ + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 47000, SDS-PAGE | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Saccharomyces cerevisiae |