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Literature summary for 2.5.1.21 extracted from

  • Nishino, T.; Katsuki, H.
    Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase (1985), Methods Enzymol., 110, 373-375.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Saccharomyces cerevisiae
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ most effective in stimulation of squalene formation, half-maximal activity at 2.5 mM Saccharomyces cerevisiae
Mg2+ Mn2+ is more effective than Mg2+ in activation of dehydrosqualene formation Saccharomyces cerevisiae
Mn2+ more effective than Mg2+ in activation of dehydrosqualene formation Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate in presence of Mn2+ Saccharomyces cerevisiae 12,13-cis-dehydrosqualene + diphosphate 12-cis-dehydrosqualene + diphosphate ?
farnesyl diphosphate + NAD(P)H
-
Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Saccharomyces cerevisiae