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Literature summary for 2.5.1.17 extracted from

  • Leal, N.A.; Park, S.D.; Kima, P.E.; Bobik, T.A.
    Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant (2003), J. Biol. Chem., 278, 9227-9234.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Bos taurus
expressed in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble from skin cells Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
Bos taurus
K+
-
Homo sapiens
Mg2+
-
Bos taurus
Mg2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
SDS-PAGE, recombinant enzyme without mitochondrial targeting sequence Homo sapiens
54000
-
calculated from amino acid sequence of recombinant enzyme without mitochondrial targeting sequence Bos taurus
55000
-
calculated from amino acid sequence of recombinant enzyme without mitochondrial targeting sequence Homo sapiens
56000
-
SDS-PAGE, recombinant enzyme with mitochondrial targeting sequence Homo sapiens
58000
-
calculated from amino acid sequence of recombinant enzyme with mitochondrial targeting sequence Bos taurus
58000
-
calculated from amino acid sequence of recombinant enzyme with mitochondrial targeting sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens Q96EY8
-
-

Purification (Commentary)

Purification (Comment) Organism
centrifugation and SDS-PAGE Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver mRNA expression detected Bos taurus
-
liver mRNA expression detected Homo sapiens
-
skin skin fibroblasts show low abundance Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
data for ATR inclusion bodies from the enzyme expressed in E. coli with no mitochondrial targeting sequence also available Bos taurus
0.047
-
pH 8.0, 37°C Bos taurus
0.047
-
bovine ATR containing mitochondrial targeting sequence, expressed in E. coli, soluble fraction Bos taurus
0.061
-
pH 8.0, 37°C Homo sapiens
0.061
-
human ATR containing mitochondrial targeting sequence, expressed in E. coli and forming inclusion bodies Homo sapiens
0.098
-
pH 8.0, 37°C Homo sapiens
0.098
-
human ATR with no mitochondrial targeting sequence, expressed in E. coli and forming inclusion bodies Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cob(I)alamin
-
Bos taurus triphosphate + coenzyme B12
-
?
ATP + cob(I)alamin
-
Homo sapiens triphosphate + coenzyme B12
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Bos taurus
8
-
assay at Homo sapiens