Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid | 86% inhibition at 0.25 mM | Bacillus anthracis | |
2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid | 46% inhibition at 0.25 mM | Staphylococcus aureus | |
2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid | 61% inhibition at 0.25 mM | Yersinia pestis | |
N-(4-(trifluoromethyl)-benzylidene)-1-(4-(trifluoromethyl))benzylamine | complete inhibition at 0.25 mM | Bacillus anthracis | |
N-(4-(trifluoromethyl)-benzylidene)-1-(4-(trifluoromethyl))benzylamine | complete inhibition at 0.25 mM | Staphylococcus aureus | |
N-(4-(trifluoromethyl)-benzylidene)-1-(4-(trifluoromethyl))benzylamine | complete inhibition at 0.25 mM | Yersinia pestis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate | Staphylococcus aureus | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate | Yersinia pestis | - |
diphosphate + 7,8-dihydropteroate | - |
? | |
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate | Bacillus anthracis | - |
diphosphate + 7,8-dihydropteroate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | Q81VW8 | - |
- |
Staphylococcus aureus | - |
- |
- |
Yersinia pestis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate | - |
Staphylococcus aureus | diphosphate + 7,8-dihydropteroate | - |
? | |
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate | - |
Yersinia pestis | diphosphate + 7,8-dihydropteroate | - |
? | |
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate | - |
Bacillus anthracis | diphosphate + 7,8-dihydropteroate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHPS | - |
Staphylococcus aureus |
DHPS | - |
Yersinia pestis |
DHPS | - |
Bacillus anthracis |
FolP | - |
Staphylococcus aureus |
FolP | - |
Yersinia pestis |
FolP | - |
Bacillus anthracis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.017 | - |
at pH 7.6 and 37°C | Staphylococcus aureus | 2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid | |
0.031 | - |
at pH 7.6 and 37°C | Yersinia pestis | 2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid | |
0.05 | - |
at pH 7.6 and 37°C | Bacillus anthracis | 2-(7-amino-1-methyl-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)propanoic acid |