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Literature summary for 2.5.1.10 extracted from

  • Nagaki, M.; Nakada, M.; Musashi, T.; Kawakami, J.; Endo, T.; Maki, Y.; Koyama, T.
    Substrate specificities of wild and mutated farnesyl diphosphate synthases: Reactivity of allylic substrate homologs having hydrophilic groups at omega-position (2009), J. Mol. Catal. B, 59, 225-230.
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
Y81D mutant yields higher condensation products than wild-type Geobacillus stearothermophilus

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
-
bifunctional geranyl diphosphate synthase EC 2.5.1.1 and farnesyl diphosphate synthase EC 2.5.1.10
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Sus scrofa
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bifunctional geranyl diphosphate synthase EC 2.5.1.1 and farnesyl diphosphate synthase EC 2.5.1.10
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methoxymethoxydimethylallyl diphosphate + isopentenyl diphosphate
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Sus scrofa methoxymethoxygeranyl diphosphate + diphosphate yield is 1% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate ?
methoxymethoxydimethylallyl diphosphate + isopentenyl diphosphate
-
Geobacillus stearothermophilus methoxymethoxygeranyl diphosphate + diphosphate yield is 5% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate. Mutant Y81D yields methoxymethoxyfarnesyl diphosphate with high efficiency ?
propoxygeranyl diphosphate + isopentenyl diphosphate
-
Geobacillus stearothermophilus propoxyfarnesyl diphosphate + diphosphate yield is 3% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate, and 63% yield for mutant Y81D, plus 6% of propoxygeranylgeranyl diphosphate ?
propoxygeranyl diphosphate + isopentenyl diphosphate
-
Sus scrofa propoxyfarnesyl diphosphate + diphosphate yield is 62% methoxymethoxygeranyl diphosphate, compared with 100% for the reaction of dimethylallyl diphosphate with isopentenyl diphosphate ?