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Literature summary for 2.5.1.10 extracted from

  • Kawasaki, T.; Hamano, Y.; Kuzuyama, T.; Itoh, N.; Seto, H.; Dairi, T.
    Interconversion of the product specificity of type I eubacterial farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase through one amino acid substitution (2003), J. Biochem., 133, 83-91.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Streptomyces argenteolus

Protein Variants

Protein Variants Comment Organism
S50L mutant enzyme produces prenyl diphosphates with the same chain lengths as the wild-type enzyme does. 1.3-1.4fold decrease in ratio of Vmax to Km-value for dimethylallyl diphosphate and isopentenyl diphosphate Streptomyces argenteolus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0159
-
dimethylallyl diphosphate mutant enzyme L58A Streptomyces argenteolus
0.0531
-
isopentenyl diphosphate cosubstrate: dimethylallyl diphosphate, wild-type enzyme Streptomyces argenteolus
0.0666
-
dimethylallyl diphosphate wild-type enzyme Streptomyces argenteolus
0.0705
-
farnesyl diphosphate mutant enzyme L58A Streptomyces argenteolus
0.221
-
isopentenyl diphosphate cosubstrate: farnesyl diphosphate, mutant enzyme L58A Streptomyces argenteolus

Organism

Organism UniProt Comment Textmining
Streptomyces argenteolus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + 2 isopentenyl diphosphate
-
Streptomyces argenteolus 2 diphosphate + trans,trans-farnesyl diphosphate
-
?
dimethylallyl diphosphate + isopentenyl diphosphate
-
Streptomyces argenteolus diphosphate + geranyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
-
Streptomyces argenteolus diphosphate + trans,trans-farnesyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
farnesyl diphosphate synthase
-
Streptomyces argenteolus
FDPSase
-
Streptomyces argenteolus
type I farnesyl diphosphate synthase
-
Streptomyces argenteolus