Organism | UniProt | Comment | Textmining |
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Escherichia coli | - |
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Synonyms | Comment | Organism |
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Kdo transferase | - |
Escherichia coli |
General Information | Comment | Organism |
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malfunction | kdtA deletion mutants are viable when lpxL and lpxM (the lauroyl- or the myristoyltransferase of lipid A biosynthesis) are overexpressed. Deletion of kdtA in strains overexpressing LpxM causes accumulation of pentaacylated lipid A with a secondary myristate moiety. None of the strains lacking kdtA grow in the presence of bile salts at any temperature or on nutrient broth at 42°C | Escherichia coli |
physiological function | the main function of Kdo transferase is to provide the right substrates for the acyltransferases LpxL and LpxM, resulting in the synthesis of penta- and hexaacylated lipid A, which is optimal for the MsbA flippase | Escherichia coli |